Similarity in Neuronal Firing Regimes across Mammalian Species
Similarity in Neuronal Firing Regimes across Mammalian Species
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DOI：
10.1523/jneurosci.0230-16.2016
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发表时间：
2016-05-25
影响因子：
5.3
通讯作者：
Shinomoto, Shigeru
中科院分区：
文献类型：
--
作者：
Mochizuki, Yasuhiro;Onaga, Tomokatsu;Shinomoto, Shigeru
大脑的结构细分被认为是功能模块，每个模块处理全局功能的一部分。此前，我们展示了猴子不同区域的神经元在不同的放电机制下工作。可能的是，放电模式反映了潜在信息处理的差异，因此，不同动物物种同源区域的放电模式可能是相似的。我们分析了小鼠、大鼠、猫和猴子的行为记录的神经元棘波序列。发射规律有系统地不同，同一物种在不同地区的差异大于不同物种在相似地区的差异。神经元放电在运动区一直是最规则的，在视觉和前额叶/额叶内侧皮质区几乎是随机的，在所有被研究的动物的海马体中都是爆发的。这表明，放电的规律性(或不规则性)在每个功能细分的神经计算中发挥着关键作用，这取决于所传递的信息的类型。
The architectonic subdivisions of the brain are believed to be functional modules, each processing parts of global functions. Previously, we showed that neurons in different regions operate in different firing regimes in monkeys. It is possible that firing regimes reflect differences in underlying information processing, and consequently the firing regimes in homologous regions across animal species might be similar. We analyzed neuronal spike trains recorded from behaving mice, rats, cats, and monkeys. The firing regularity differed systematically, with differences across regions in one species being greater than the differences in similar areas across species. Neuronal firing was consistently most regular in motor areas, nearly random in visual and prefrontal/medial prefrontal cortical areas, and bursting in the hippocampus in all animals examined. This suggests that firing regularity (or irregularity) plays a key role in neural computation in each functional subdivision, depending on the types of information being carried.