Integration of Enzymatic Catalysts in a Continuous Reactive Distillation Column: Reaction Kinetics and Process Simulation
Integration of Enzymatic Catalysts in a Continuous Reactive Distillation Column: Reaction Kinetics and Process Simulation
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DOI：
10.1021/ie502827f
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发表时间：
2014-12
影响因子：
4.2
通讯作者：
René Heils;Alexander Niesbach;Matthias Wierschem;D. Claus;Sebastian Soboll;P. Lutze;I. Smirnova
中科院分区：
文献类型：
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作者：
René Heils;Alexander Niesbach;Matthias Wierschem;D. Claus;Sebastian Soboll;P. Lutze;I. Smirnova
这项工作提出了连续运行的反应蒸馏塔中酶促反应的可行性研究。作为模型反应，考虑了在脂肪酶 CALB 存在下丁酸乙酯与正丁醇的酯交换反应。为了在蒸馏塔中使用，脂肪酶 CALB 通过包埋在疏水二氧化硅干凝胶中进行固定，并以颗粒形式引入催化填料 Katapak-SP-11 中。通过实验确定了不同浓度和温度范围的反应动力学，并通过 Michaelis-Menten 双底物动力学模型结合阿伦尼乌斯模型进行了描述。利用这些动力学数据，使用经过 DN50 中试规模塔验证的 Aspen Custom Modeler 非平衡阶段模型进行过程模拟。反应部分的正丁醇浓度保持较低，以减少对酶的抑制作用。为了优化设置和操作条件，转化率超过 90%...
This work presents a feasibility study for an enzymatic reaction in a continuously operated reactive distillation column. As a model reaction, the transesterification of ethyl butyrate with n-butanol in the presence of lipase CALB was considered. For use in the distillation column, lipase CALB was immobilized by entrapment in a hydrophobic silica xerogel and introduced as granulate into the catalytic packing Katapak-SP-11. The reaction kinetics was experimentally determined for different concentration and temperature ranges and described by means of the Michaelis–Menten double-substrate kinetic model in combination with the Arrhenius model. With these kinetic data, process simulations were carried out with an Aspen Custom Modeler nonequilibrium-stage model validated for a DN50 pilot-scale column. The concentration of n-butanol in the reactive section was maintained low to decrease the inhibiting effects on the enzyme. For an optimized setup and operating conditions, conversion rates of more than 90% were ...