Insomnia and depression
Insomnia and depression
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DOI：
10.1016/s1389-9457(08)70010-8
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发表时间：
2008-09-01
期刊：
影响因子：
4.8
通讯作者：
Peterson, Michael J.
中科院分区：
文献类型：
--
作者：
Benca, Ruth M.;Peterson, Michael J.
很明显，失眠和抑郁症密切相关，这可能表明神经生物学存在重叠。尽管在了解这些疾病如何相互关联方面已经取得了很大进展，但将它们联系起来的确切神经生物学机制仍然难以捉摸。抑郁症患者的睡眠变化可能与神经传递异常、遗传多态性、HPA 过度活跃、可塑性受损或很可能是多种因素的组合有关。因此，睡眠评估必须超越传统的多导睡眠图，纳入更广泛的客观测量，以期揭示被认为是失眠和抑郁症背后的常见神经生物学。 (C) 2008 年由 Elsevier B.V 出版。保留所有权利。
It is clear that insomnia and depression are intimately related, which may Suggest an overlapping neurobiology. Although much progress has been made toward understanding how these disorders relate to each other, the exact neurobiological mechanisms that link them remain elusive. Sleep changes in depression may be associated with abnormal neurotransmission, genetic polymorphisms, HPA overactivity, impaired plasticity, or most likely a combination of factors. It is therefore crucial that sleep assessments go beyond traditional polysomnography to include a more expanded set of objective measures in the hope that these will uncover the common neurobiology that is thought to underlie insomnia and depression. (C) 2008 published by Elsevier B.V. All rights reserved.