Good cop, bad cop: Polyamines play both sides in host immunity and viral replication.
Good cop, bad cop: Polyamines play both sides in host immunity and viral replication.
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DOI：
10.1016/j.semcdb.2022.12.004
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发表时间：
2023-01
影响因子：
7.3
通讯作者：
Yazmin E Cruz-Pulido;Bryan C. Mounce
中科院分区：
文献类型：
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作者：
Yazmin E Cruz-Pulido;Bryan C. Mounce
病毒依赖宿主细胞提供基因组复制和粒子组装所需的能量和合成机制。由于病毒对宿主细胞的依赖性，病毒已经进化出多种机制，通过这些机制它们可以诱导宿主细胞中的代谢变化以适应它们的特定需求。宿主免疫应答还涉及代谢变化，以便能够对病毒攻击作出反应。多胺是小的普遍表达的聚阳离子，并且它们的代谢对于病毒复制和充分的宿主免疫应答至关重要。这是由于多胺具有多种功能，从浓缩DNA到通过eIF5A的羟腐胺酸化增强含聚脯氨酸蛋白的翻译。在这里，我们回顾了病毒利用多胺的不同机制，以及免疫细胞利用多胺的功能的机制。此外，我们强调潜在的途径，进一步研究的主机病毒接口。
Viruses rely on host cells for energy and synthesis machinery required for genome replication and particle assembly. Due to the dependence of viruses on host cells, viruses have evolved multiple mechanisms by which they can induce metabolic changes in the host cell to suit their specific requirements. The host immune response also involves metabolic changes to be able to react to viral insult. Polyamines are small ubiquitously expressed polycations, and their metabolism is critical for viral replication and an adequate host immune response. This is due to the variety of functions that polyamines have, ranging from condensing DNA to enhancing the translation of polyproline-containing proteins through the hypusination of eIF5A. Here, we review the diverse mechanisms by which viruses exploit polyamines, as well as the mechanisms by which immune cells utilize polyamines for their functions. Furthermore, we highlight potential avenues for further study of the host-virus interface.