Associations between intermediate age-related macular degeneration and lutein and zeaxanthin in the carotenoids in age-related eye disease study (CAREDS) - Ancillary study of the women's health initiative
Associations between intermediate age-related macular degeneration and lutein and zeaxanthin in the carotenoids in age-related eye disease study (CAREDS) - Ancillary study of the women's health initiative
复制标题
DOI：
10.1001/archopht.124.8.1151
复制
发表时间：
2006-08-01
影响因子：
--
通讯作者：
Mares, Julie A.
中科院分区：
文献类型：
--
作者：
Moeller, Suzen M.;Parekh, Niyati;Mares, Julie A.
目的：探讨膳食叶黄素加玉米黄质与中度老年性黄斑变性（AMD）的关系。设计：在爱奥华州、威斯康辛州和俄勒冈州，年龄在50至79岁之间的女性，叶黄素和玉米黄质的摄入量在基线时高于第78百分位（高），低于第28百分位（低），在4至7年后被招募到类胡萝卜素与年龄相关眼病研究（CAREDS）中，通过眼底照片确定AMD的存在。在考虑了潜在协变量后，Logistic回归分析检查了1787名CAREDS参与者中AMD的患病率。结果：调整年龄后，叶黄素+玉米黄质摄入高组和低组之间的中度AMD患病率无统计学差异（优势比为0.96；95%可信区间为0.75-1.23）。限制对年龄小于75岁、稳定摄入叶黄素和玉米黄质、没有慢性疾病史（通常与饮食改变有关）的女性进行分析，显著降低了优势比（0.57；95%可信区间为0.34-0.95）。对34名参与者的晚期AMD的探索性分析结果显示，总体样本和年龄小于75岁的女性之间存在保护作用，但在统计学上不显著。结论：富含叶黄素和玉米黄质的饮食可预防75岁以下健康女性的中度黄斑变性。
Objective: To evaluate the relationship between dietary lutein plus zeaxanthin and intermediate age-related macular degeneration (AMD).Design: Women aged 50 to 79 years in Iowa, Wisconsin, and Oregon with intake of lutein plus zeaxanthin above the 78th (high) and below the 28th (low) percentiles at baseline in the Women's Health Initiative Observational Study were recruited 4 to 7 years later into the Carotenoids in Age-Related Eye Disease Study (CAREDS), when the presence of AMD was determined by fundus photographs. Logistic regression analyses examined the prevalence of AMD in 1787 CAREDS participants, after accounting for potential covariates.Results: The prevalence of intermediate AMD was not statistically different between the high and low lutein plus zeaxanthin intake recruitment groups after adjusting for age ( odds ratio, 0.96; 95% confidence interval, 0.75-1.23). Limiting analyses to women younger than 75 years with stable intake of lutein plus zeaxanthin, without a history of chronic diseases that are often associated with diet changes, substantially lowered odds ratios (0.57; 95% confidence interval, 0.34-0.95). Exploratory analyses of advanced AMD in 34 participants resulted in protective, but statistically nonsignificant, associations in the overall sample and in women younger than 75 years.Conclusion: Diets rich in lutein plus zeaxanthin may protect against intermediate AMD in healthy women younger than 75 years.