IMPORTANCE OF SCORING SYSTEMS IN PROGNOSTICATING MENINGOCOCCEMIA
IMPORTANCE OF SCORING SYSTEMS IN PROGNOSTICATING MENINGOCOCCEMIA
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评分系统在预测脑膜炎球菌病中的重要性
DOI：
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发表时间：
2005
影响因子：
1.6
通讯作者：
A. Namini
中科院分区：
文献类型：
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作者：
A. Namini
背景：脑膜炎球菌病在世界范围内呈地方性或流行性分布，总死亡率为 8% 至 10%，主要发生在有脑膜炎球菌血症体征和症状的患者中。一些研究人员已经设计了评分系统，使用就诊时可用的临床和实验室参数来预测感染的结果。本研究旨在确定患者中人口统计学、临床和实验室参数的分布以及个体 Stiehm 和 Damrosch 成分的相对频率。
方法：这是一项前瞻性描述性研究，对 1997 年至 2002 年间伊朗伊斯法罕 Al-Zahra 大学医院（成人和儿科病房）收治的明确诊断为脑膜炎球菌感染的患者进行。病例为 140 名患者 [99（70.7%）名男性和 41（29.3%）名女性]，年龄为 1 至 50 岁。 (25.5±1.32)。通过填写清单收集数据。应用SSPS软件通过卡方检验分析数据。
结果：在本研究中，各个 Stiehm 和 Damrosch 成分的相对频率如下：低血压（10.7%）、外周血白细胞计数 <10,000/mm3（39.3%）、白细胞减少（11.5%）、ESR<10 mm/hr（19.3%）、昏迷（6.4%）、早期广泛性瘀点（18%）、无脑膜炎 （13.6%）。总体死亡率为（10.7%）。
结论：脑膜炎球菌仍然是杀手，其对男性的影响大于女性。青少年比其他年龄段的人面临更大的风险。我们研究中的死亡率略高于建议值 (10.7%)。我们建议使用评分系统早期分离预后不良的患者，为他们提供更多特殊护理。
关键词：脑膜炎球菌血症、评分系统、脑膜炎球菌感染
Background: Meningococcal diseases occur with a worldwide distribution as endemic or in epidemics with an overall mortality rate of 8% to 10%, mainly in patients with signs and symptoms of meningococcemia. Several investigators have devised scoring systems using clinical and laboratory parameters available at the time of presentation to prognosticate the outcome of the infection. This study was designed to determine the distribution of demographic, clinical and laboratory parameters among our patients and the relative frequency of individual Stiehm and Damrosch components.
Methods: This was a prospective descriptive study, performed on patients with definite diagnosis of meningococcal infection admitted to Al-Zahra University hospital (adult and pediatric wards), Isfahan, Iran, between 1997 and 2002. The cases were 140 patients [99(70.7%) males and 41(29.3%)females] from 1 to 50 years old (25.5±1.32). Data were collected by filling checklists. SSPS software was applied to analyze the data using chi-square test.
Results: In this study, the relative frequency of individual Stiehm and Damrosch components were as follows: hypotension (10.7%), peripheral white blood cell count <10,000/mm3 (39.3%), leukopenia (11.5%), ESR<10 mm/hr (19.3%), coma (6.4%), early widespread petechiae (18%), absence of meningitis (13.6%). Overall mortality rate was (10.7%).
Conclusion: Meningococci are still killers, they affect men more than women. Teenagers are at more risk than other age groups. Mortality in our study was a little higher than what is suggested (10.7%). we recommend using scoring systems for early separation of poor prognostic patients to provide them with more special care.
Keywords: Meningococcemia, Scoring systems, Meningococcal infection