Ferrocene-modified pyrimidine nucleosides: synthesis, structure and electrochemistry.
Ferrocene-modified pyrimidine nucleosides: synthesis, structure and electrochemistry.
复制标题
二茂铁修饰的嘧啶核苷：合成、结构和电化学。
DOI：
10.1039/b608077d
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发表时间：
2006
影响因子：
4
通讯作者：
H. Kraatz
中科院分区：
文献类型：
--
作者：
Haifeng Song;Xiaohong Li;Yitao Long;G. Schatte;H. Kraatz
本文报道了两种可能用于研究DNA电子转移的二茂铁修饰的嘧啶核苷的合成、晶体结构和电化学结果。Fc通过Stille偶联反应直接连接到脱氧尿嘧啶和脱氧胞苷的5位上。用标准固相法将fc修饰的尿苷掺入DNA三核苷酸中。用单晶x射线分析确定了相应脱三烷基化合物的结构。用循环伏安法对所有化合物进行了电化学研究，发现了可逆的氧化还原过程。
This paper reports syntheses, crystal structures and electrochemical results for two ferrocene(Fc)-modified pyrimidine nucleosides that could potentially be used for investigating electron transfer in DNA. Fc was directly attached to the 5-position of deoxyuridine and deoxycytidine via the Stille coupling reaction. Fc-modified uridine was incorporated into DNA trinucleotides with standard solid-phase synthesis. The structures of corresponding detritylated compounds were determined by single-crystal X-ray analysis. Electrochemical investigations of all compounds by cyclic voltammetry revealed reversible redox processes.
影响因子：
14.9
作者：
Kelley, SO;Boon, EM;Hill, MG
通讯作者：
Hill, MG
影响因子：
4.7
作者：
Kelley, SO;Barton, JK;Hill, MG
通讯作者：
Hill, MG