Angiosarcoma developing in a patient with neurofibromatosis (von Recklinghausen's disease)
Angiosarcoma developing in a patient with neurofibromatosis (von Recklinghausen's disease)
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神经纤维瘤病（冯·雷克林豪森氏病）患者出现血管肉瘤
DOI：
10.1002/1097-0142(19810301)47:5
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发表时间：
1981
期刊：
影响因子：
6.2
通讯作者：
E. Campbell
中科院分区：
文献类型：
--
作者：
David I. Millstein;Chik‐Kwun Tang;E. Campbell
作者提出一个血管肉瘤的阴囊和阴茎。该疾病发生在一名61岁的男性，有长期的神经纤维瘤病（von Recklinghausen病）病史。本文描述了其组织学和超微结构特征。作者推测，血管肉瘤发生在没有神经纤维瘤病组织学证据的位置，可能代表了血管组织中异常基因组的表达。血管肉瘤仅对放射治疗有暂时性反应，手术后复发，对阿霉素、更生霉素或顺铂无反应。病人在血管肉瘤发作三年后死亡。Cancer 47：950-954，1981.
The authors present an angiosarcoma of the scrotum and penis. The disease occurred in a 61‐year‐old man with a long history of neurofibromatosis (von Recklinghausen's disease). The histologic and ultrastructural features are described. The authors speculate that the angiosarcoma, which developed in a location without histologic evidence of neurofibromatosis, possibly represents an expression of an abnormal genome in vascular tissue. The angiosarcoma responded to radiation therapy only temporarily, recurred after surgery, and did not respond to Adriamycin, dactinomycin or cis‐platinum. The patient died three years after the onset of his angiosarcoma. Cancer 47:950–954, 1981.