Spatial memory deficits in patients with lesions affecting the medial temporal neocortex
Spatial memory deficits in patients with lesions affecting the medial temporal neocortex
复制标题
内侧颞新皮质病变患者的空间记忆缺陷
作者：
C. Ploner;B. Gaymard;N. Ehrlé;S. Rivaud;M. Baulac;S. Brandt;S. Clemenceau;S. Samson;C. Pierrot
在猴子的病变研究表明，内侧颞叶（MTL）的新皮质亚区进行独立的海马结构的记忆功能。本研究探讨MTL亚区的空间记忆在人类可能的差异贡献。在右侧MTL术后病变患者（仅限于海马结构（n = 3）或包括相邻的新皮质（n = 5））和10名对照组中，记录了朝向记忆空间线索（记忆引导的扫视）的眼球运动，记忆延迟长达30秒。虽然选择性海马病变患者的扫视目标错误与对照组没有差异，扫视目标错误的患者额外的新皮层参与显示出显着的和对侧显着增加记忆延迟超过20秒。我们的结论是，人类内侧颞叶新皮质具有独立于海马结构的空间记忆功能，并且与空间短期记忆不同。《神经学年鉴》1999;45：312-319
Lesion studies in monkeys suggest that neocortical subregions of the medial temporal lobe (MTL) carry memory functions independent of the hippocampal formation. The present study investigates possible differential contributions of MTL subregions to spatial memory in humans. Eye movements toward remembered spatial cues (memory‐guided saccades) with unpredictably varied memorization delays of up to 30 seconds were recorded in patients with postsurgical lesions of the right MTL, either restricted to the hippocampal formation (n = 3) or including the adjacent neocortex (n = 5) and in 10 controls. Although saccadic targeting errors of patients with selective hippocampal lesions did not differ from controls, saccadic targeting errors of patients with additional neocortical involvement showed a significant and contralaterally pronounced increase at memorization delays above 20 seconds. We conclude that the human medial temporal neocortex carries spatial memory functions independent of the hippocampal formation and distinct from spatial short‐term memory. Ann Neurol 1999;45:312–319