Increased nitric oxide elimination from the airways after smoking cessation.
Increased nitric oxide elimination from the airways after smoking cessation.
复制标题
戒烟后气道中一氧化氮的消除增加。
DOI：
10.1042/cs1030015
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发表时间：
2002
期刊：
影响因子：
6
通讯作者：
H. Hedenström
中科院分区：
文献类型：
--
作者：
M. Högman;T. Holmkvist;R. Wålinder;P. Meriläinen;D. Lúdvíksdóttir;L. Håkansson;H. Hedenström
研究发现，吸烟者呼出的一氧化氮（NO）水平较低。本研究的目的是调查呼吸系统中一氧化氮的减少发生在哪里，以及这种减少是否受到戒烟的影响。对吸烟者（n=20）和非吸烟对照组（n=30）的呼出一氧化氮进行了测量。在戒烟后1、2和4周，对9名吸烟者呼出的一氧化氮进行了分析。在0.1升/秒的流速下，吸烟者呼出的NO水平（4+/-2 p.p.b）明显低于非吸烟者（7+/-5 p.p.b； P=0.007）。对肺不同部位贡献的计算表明，吸烟者的气道NO通量显著低于非吸烟者（14+/-10与36+/-26 nl/min相比，P=0.0001），肺泡分数显著高于非吸烟者（2.1+/-0.8与1.5+/-0.9 p.p.b相比，P=0.006）。9名吸烟受试者戒烟4周后，气道NO通量增加28+/-17 nl/min，与对照组无显著差异。综上所述，吸烟者气道内源性NO生成减少，但在戒烟后4周可恢复到正常水平。吸烟者肺泡一氧化氮含量增加，这可能是肺损伤的诊断标志。因此，当吸烟者决定戒烟时，NO监测可用于指示改善情况。
Smokers have been found to have low exhaled nitric oxide (NO) levels. The aim of the present study was to investigate where in the respiratory system the decrease in NO occurs, and whether this decrease was affected by smoking cessation. Measurements of exhaled NO were carried out in smokers (n=20) and non-smoking control subjects (n=30). In nine of the smokers, exhaled NO was analysed 1, 2 and 4 weeks after smoking cessation. The level of exhaled NO at a flow rate of 0.1 litre/s was significantly lower in smokers (4+/-2 p.p.b.) than in non-smokers (7+/-5 p.p.b.; P=0.007). A calculation of the contributions from different areas of the lung showed that the NO flux from the airways was significantly lower (14+/-10 compared with 36+/-26 nl/min; P=0.0001) and the alveolar fraction was significantly higher (2.1+/-0.8 compared with 1.5+/-0.9 p.p.b.; P=0.006) in smokers than in non-smokers. Nine smoking subjects refrained from smoking for 4 weeks, and this resulted in increased NO flux from the airways of 28+/-17 nl/min, which was no longer significantly different from controls. In conclusion, endogenous production of NO in the airways is decreased in smokers, but can be restored to normal values by 4 weeks after cessation of smoking. Smokers have an increased alveolar fraction of NO, and this might be a diagnostic sign of lung damage. Thus NO monitoring can be used to indicate improvements when a smoker decides to stop smoking.