Staphylococcus aureus surface protein SasG contributes to intercellular autoaggregation of Staphylococcus aureus
Staphylococcus aureus surface protein SasG contributes to intercellular autoaggregation of Staphylococcus aureus
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DOI：
10.1016/j.bbrc.2008.10.134
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发表时间：
2008-12-26
影响因子：
3.1
通讯作者：
Ohta, Toshiko
中科院分区：
文献类型：
--
作者：
Kuroda, Makoto;Ito, Ryuta;Ohta, Toshiko
Staphylococcus aureus surface protein G (SasG) is one of cell surface proteins with cell-wall sorting motif. The sasG mutant showed significantly reduced cell aggregation and biofilm formation. SasG is comprised of variable A domain and multiple tandem repeats of B domain, native-PAGE and in vitro formaldehyde cross-linking experiments revealed that the recombinant protein of the A domain showed homo-oligomerization as an octamer, but B domain did not. This study shows that SasG-A domain contributes to intercellular autoaggregation by homo-oligomerization, and that may facilitate the adherence to host-tissues in the infection of S. aureus. (C) 2008 Elsevier Inc. All rights reserved.
