BACTERIAL POPULATIONS OF SMALL-INTESTINE IN UREMIA
BACTERIAL POPULATIONS OF SMALL-INTESTINE IN UREMIA
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DOI：
10.1159/000181424
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发表时间：
1978-01-01
期刊：
影响因子：
2.5
通讯作者：
GORDON, SJ
中科院分区：
文献类型：
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作者：
SIMENHOFF, ML;SAUKKONEN, JJ;GORDON, SJ
对15例慢性肾功能不全患者和盲袢综合征患者的小肠植物群进行了比较。9例患者接受定期血液透析，高蛋白摄入，6例（血清肌酐7.5 - 12.5 mg/dl）维持低蛋白饮食。慢性肾脏病患者十二指肠和空肠中厌氧菌和需氧菌的微生物植物群显著增加，与盲袢受试者的数量相当。两组的组成没有显著差异。某些微生物可能代谢从饮食和胆汁到达肠腔的底物，并可能产生可能导致尿毒症毒性或吸收不良的毒性代谢产物。
The small intestinal bacterial flora of 15 patients with chronic renal insufficiency was compared with that of subjects with blind loop syndrome. 9 patients were on regular hemodialysis with high protein intake and 6 (serum creatinine 7.5 to 12.5 mg/dl) were maintained on low protein diet. The chronic renal patients harbored a greatly increased microbial flora of both anaerobes and aerobes in the duodenum and jejunum, quantitatively comparable to those in blind loop subjects. The composition did not differ significantly in the two groups. Some organisms may have the potential to metabolize substrates which reach the intestinal lumen from the diet and bile, and perhaps to generate toxic metabolites that could contribute to uremic toxicity or malabsorption.