Stabilizing Circadian Rhythms in Bipolar Disorder by Chaos Control Methods
Stabilizing Circadian Rhythms in Bipolar Disorder by Chaos Control Methods
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DOI：
10.3389/fams.2020.562929
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发表时间：
2020-10
期刊：
影响因子：
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通讯作者：
S. Nobukawa;H. Nishimura;Hirotaka Doho;Tetsuya Takahashi
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作者：
S. Nobukawa;H. Nishimura;Hirotaka Doho;Tetsuya Takahashi
双相情感障碍（BD）涉及躁狂症和抑郁症之间的情绪波动，在长期治疗期间与多次复发、高自杀率和高发病率有关。在双相障碍中，通过每日情绪评分和活动记录测量的昼夜节律受到干扰。时间疗法已成为一种潜在的双相障碍治疗方法，因为它稳定了紊乱的昼夜节律并改善了双相障碍症状。具体治疗包括光疗和联合治疗（光疗和药物）。然而，一些患者难以适应光疗；不适当的光照和持续时间增加了诱导混合状态和出现诸如轻躁狂和自主神经过度激活等病症的风险。因此，设计优化双相障碍时间疗法的方法非常重要。我们的目标是建立基于延迟反馈方法的额叶皮质反馈信号，作为混沌控制方法之一，以稳定紊乱的双相障碍昼夜节律。本研究的具体步骤如下：首先，利用额叶皮质和下丘脑神经系统再现双相障碍昼夜节律，这是之前提出的。其次，利用分岔分析的方法得到了时滞反馈信号。第三，通过复杂度指标和反馈项中有无随机噪声条件下的功率谱来评价延迟反馈信号的效果。我们发现，将延迟反馈信号应用于额叶皮层神经活动，可以诱导受干扰复体的昼夜节律周期状态，治疗双相障碍是可行的，但当反馈项中噪声的影响增加时，稳定效果减弱。总之，我们开发了一种利用昼夜节律神经系统稳定BD紊乱昼夜节律的方法。本研究强调了混沌控制方法治疗双相障碍的潜在用途。
Bipolar disorder (BD), which involves mood swings between mania and depression, is associated with multiple relapses during long-term treatment and high suicide and morbidity rates. In BD, the circadian rhythms, which are measured by daily mood scores and actigraphic records, are disturbed. Chronotherapy has emerged as a potential treatment for BD because it stabilizes the disturbed circadian rhythms and improves BD symptoms. Concrete treatments include light therapy and combination therapy (light therapy and drugs). However, some patients have difficulty adjusting to light therapy; inappropriate light and duration of treatment increase risks for inducing mixed states and the emergence of conditions, such as hypomania and autonomic hyperactivation. Therefore, it is important to devise methods for optimizing chronotherapy for BD. We aimed to develop feedback signals for the frontal cortex, which were based on the delayed feedback method as one of the chaos control methods, to stabilize the disturbed circadian rhythms of BD. Concrete procedures of this study are indicated as follows: first, circadian rhythms of BD are reproduced using the frontal cortex and hypothalamus neural system, which has been previously proposed. Second, the delayed feedback signal is developed by using bifurcation analysis. Third, the effect of delayed feedback signal is evaluated by index for complexity, and power spectrum under the condition with/without stochastic noise in feedback term. We found that application of the delayed feedback signal to the frontal cortical neural activity induces the periodic state of circadian rhythms from the disturbed complex and is feasible for treating BD. However, when increasing the influence of noise in feedback term, the stabilizing effect is diminished. In conclusion, we developed a stabilizing method for disturbed circadian rhythms of BD using the circadian neural systems. The present study highlights the potential usefulness of the chaos control method for treating BD.