Endometrial thickness and IVF cycle outcomes: a meta-analysis
Endometrial thickness and IVF cycle outcomes: a meta-analysis
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DOI：
10.1016/j.rbmo.2019.09.005
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发表时间：
2020-01-01
影响因子：
4
通讯作者：
Zhang, Yunshan
中科院分区：
文献类型：
--
作者：
Gao, Ge;Cui, Xianfeng;Zhang, Yunshan
研究问题：在这项荟萃分析中，探讨了子宫内膜厚度（EMT）与IVF后周期结局之间的关系。EMT和周期结果之间的关联，根据研究和个人特征进行了assessed.Design：研究评估EMT和妊娠，植入，流产，活产或持续妊娠和异位妊娠率在体外受精后的个人之间的关联确定PubMed，Embase和科克伦图书馆（从他们成立到2018年12月）。采用随机效应模型计算合并优势比和95%置信区间，共检索到9项前瞻性研究和21项回顾性研究，包括88,056个周期。总体优势比表明，EMT较低的女性妊娠率低于EMT较高的女性（n = 30，OR 0.61; 95% CI 0.52 - 0.70; P < 0.001）。此外，EMT较低女性的着床率显著降低（n = 9，OR 0.49; 95% CI 0.32 - 0.74; P = 0.001）。此外，EMT和流产率之间没有显著相关性（n = 12）。此外，EMT较低的女性与活产率或继续妊娠率降低相关（11项研究，OR 0.60; 95%CI 0.48 - 0.73; P < 0.001）。结论：EMT越低，妊娠率、着床率、活产率和继续妊娠率越低。
Research question: In this meta-analysis, the association between endometrial thickness (EMT) and cycle outcomes after IVF is explored. Associations between EMT and cycle outcomes according to study and individual characteristics were also assessed.Design: Studies evaluating associations between EMT and pregnancy, implantation, miscarriage, live birth or ongoing pregnancy and ectopic pregnancy rates in individuals after IVF were identified on PubMed, Embase and the Cochrane Library (from their inception up to December 2018). Pooled odds ratios with 95% confidence intervals, calculated using the random-effects model, were used.Results: Nine prospective and 21 retrospective studies, including a total of 88,056 cycles, were retrieved. The summary odds ratios indicated that women with lower EMT were associated with lower pregnancy rates than those with higher EMT (n = 30, OR 0.61; 95% CI 0.52 to 0.70; P < 0.001). Moreover, the implantation rate in women with lower EMT was significantly reduced (n = 9, OR 0.49; 95% CI 0.32 to 0.74; P = 0.001). Furthermore, no significant association was found between EMT and the miscarriage rate (n = 12). In addition, women with lower EMT were associated with reduced live birth or ongoing pregnancy rate (11 studies, OR 0.60; 95% CI 0.48 to 0.73; P < 0.001). Finally, the incidence of ectopic pregnancy rate between lower and higher EMT showed no statistically significant association (n = 3).Conclusions: Lower EMT was associated with lower pregnancy, implantation and live birth or ongoing pregnancy rates.