Gender differences in the effect of repetitive transcranial magnetic stimulation in schizophrenia
Gender differences in the effect of repetitive transcranial magnetic stimulation in schizophrenia
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DOI：
10.1016/s0165-1781(03)00170-7
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发表时间：
2003-08-30
影响因子：
11.3
通讯作者：
Rollnik, J
中科院分区：
文献类型：
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作者：
Huber, TJ;Schneider, U;Rollnik, J
重复经颅磁刺激（rTMS）可能是有益的精神分裂症，可能通过逆转治疗前的前额叶功能减退。12例精神分裂症患者（8男，4女）进行了高频rTMS的优势背外侧前额叶皮层。他们在rTMS前后进行了数字连接测试，该测试评估了与额叶相关的认知过程。女性在rTMS后的测试中有明显改善，而男性则没有显着变化。在rTMS后的临床测量中没有相应的性别差异。性别差异的反应rTMS的初步调查结果，反映了性能的数字连接测试，建议需要调查更多的精神分裂症的男性和女性，更深入的检查rTMS对认知功能的影响。(C)2003爱思唯尔爱尔兰有限公司保留所有权利。
Repetitive transcranial magnetic stimulation (rTMS) can be beneficial in schizophrenia, possibly through a reversal of pre-treatment hypofrontality. Twelve schizophrenic patients (8 men, 4 women) were treated with high-frequency rTMS of the dominant dorsolateral prefrontal cortex. Their performance of the number-connection test, which assesses cognitive processes related to the frontal lobe, was evaluated before and after rTMS. Women improved markedly on the test after rTMS, whereas men did not show a significant change. There were no corresponding sex differences in clinical measures after rTMS. The preliminary findings of sex differences in the response to rTMS, as reflected by performance on the number-connection test, suggest the need for investigations of a greater number of schizophrenic men and women with a more intensive examination of the effects of rTMS on cognitive functions. (C) 2003 Elsevier Ireland Ltd. All rights reserved.