Sedative and cardiovascular effects of romifidine, alone and in combination with butorphanol, in the horse.
Sedative and cardiovascular effects of romifidine, alone and in combination with butorphanol, in the horse.
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DOI：
10.1111/j.1467-2995.1991.tb00008.x
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发表时间：
1991-01-01
期刊：
影响因子：
--
通讯作者：
Goossens, L.
中科院分区：
文献类型：
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作者：
Clarke, K. W.;England, G. C. W.;Goossens, L.
对4匹小马和1匹纯种马分别进行罗米定（40和80 g/kg bwt）单用和丁托啡酚（50 g/kg bwt）联用的行为学和镇静作用的研究。通过降低头部以及对施加的触摸、视觉和声音刺激的反应来评估明显的镇静。与单独使用相同剂量的罗米非定相比，与布托啡诺联合使用减少了动物对强加刺激的反应。在罗米非定/丁托啡诺联合用药后，出现口吻震颤，一些动物试图向前行走。在一个单独的系列中，研究了单独静脉注射罗米定（80 g/kg体重）或与丁托啡诺（50 g/kg体重）的心肺作用。罗米非定和罗米非定/布托啡诺联用引起类似的心血管变化，即心动过缓伴心脏传导阻滞，高血压继发低血压。罗米非定引起动脉氧张力的短暂下降，动脉二氧化碳张力在90分钟记录期结束时显着增加。罗米非定/丁托啡诺联合用药后15分钟动脉二氧化碳张力明显高于单独罗米非定。50 g/kg体重静脉注射丁托啡诺可降低罗米定镇静马对施加刺激的反应。与罗米非定单独用药相比，联合用药没有产生心血管方面的改变，但确实增加了呼吸抑制的程度。
The behavioural and sedative effects of i.v. romifidine (40 and 80 g/kg bwt) alone or in combination with i.v. butorphanol (50 g/kg bwt) were investigated in 4 ponies and 1 Thoroughbred horse. Apparent sedation, as judged by the lowering of the head, and by the response to imposed touch, visual and sound stimuli was assessed. The combination with butorphanol reduced the animals' response to imposed stimuli when compared with the effect of the same dose of romifidine alone. Following the administration of romifidine/butorphanol combinations muzzle tremor was noted and some animals attempted to walk forward. In a separate series, the cardiopulmonary effects of i.v. romifidine (80 g/kg bwt) alone, or in combination with butorphanol (50 g/kg bwt) were investigated. Romifidine and the romifidine/butorphanol combination caused similar cardiovascular changes, these being bradycardia with heart block, and hypertension followed by hypotension. Romifidine caused a transient decrease in arterial oxygen tensions and arterial carbon dioxide tensions had increased significantly by the end of the 90 min recording period. Romifidine/butorphanol combinations produced significantly higher arterial carbon dioxide tensions during the first 15 min after drug administration than did romifidine alone. Butorphanol at 50 g/kg bwt i.v. reduced the response to imposed stimuli in horses sedated with romifidine. The combination produced no cardiovascular changes beyond those induced by romifidine alone, but did increase the degree of respiratory depression.