Monitoring and control of amygdala neurofeedback involves distributed information processing in the human brain
Monitoring and control of amygdala neurofeedback involves distributed information processing in the human brain
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DOI：
10.1002/hbm.24057
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发表时间：
2018-07-01
影响因子：
4.8
通讯作者：
Ende, Gabriele
中科院分区：
文献类型：
--
作者：
Paret, Christian;Zaehringer, Jenny;Ende, Gabriele
脑机接口通过脑源性反馈（神经反馈）提供对神经活动的有意识访问。个体的监测和控制反馈的能力是有效的神经反馈治疗的两个必要过程，但其潜在的功能性神经解剖学仍然存在争议。在这项研究中，健康的受试者接受来自他们的杏仁核反应的负面图片的视觉反馈。激活和功能连接进行了分析，以解开大脑区域在不同过程中的作用。反馈监测映射到丘脑，腹内侧前额叶皮层（vmPFC），腹侧纹状体（VS），和喙PFC。VS响应反馈对应的指令，而rPFC活动区分条件和预测杏仁核调节。对照组涉及外侧PFC、前扣带和小脑。监测和控制活动在VS和丘脑重叠。扩展目前的神经反馈的神经模型，本研究介绍了监测和控制的反馈解剖分离的过程，并建议他们在自愿神经调节的重要作用。
Brain-computer interfaces provide conscious access to neural activity by means of brain-derived feedback (neurofeedback). An individual's abilities to monitor and control feedback are two necessary processes for effective neurofeedback therapy, yet their underlying functional neuroanatomy is still being debated. In this study, healthy subjects received visual feedback from their amygdala response to negative pictures. Activation and functional connectivity were analyzed to disentangle the role of brain regions in different processes. Feedback monitoring was mapped to the thalamus, ventromedial prefrontal cortex (vmPFC), ventral striatum (VS), and rostral PFC. The VS responded to feedback corresponding to instructions while rPFC activity differentiated between conditions and predicted amygdala regulation. Control involved the lateral PFC, anterior cingulate, and insula. Monitoring and control activity overlapped in the VS and thalamus. Extending current neural models of neurofeedback, this study introduces monitoring and control of feedback as anatomically dissociated processes, and suggests their important role in voluntary neuromodulation.