Palladium-Catalyzed Monofluoromethylation of Arylboronic Esters with Fluoromethyl Iodide
Palladium-Catalyzed Monofluoromethylation of Arylboronic Esters with Fluoromethyl Iodide
复制标题
钯催化氟甲基碘对芳基硼酯的单氟甲基化
DOI：
10.1021/acs.orglett.5b01361
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发表时间：
2015-06-19
期刊：
影响因子：
5.2
通讯作者：
Hu, Jinbo
中科院分区：
文献类型：
--
作者：
Hu, Jingyu;Gao, Bing;Hu, Jinbo
报道了首次钯催化芳基硼酯直接单氟甲基化制备单氟甲基芳烃。该反应通常在室温下4小时内进行，具有良好的官能团耐受性。采用卤素交换法制备了单氟甲基化剂CH2FI。
The first palladium-catalyzed direct monofluoromethylation of arylboronic esters to produce monofluoromethyl arenes is reported. The reaction is typically carried out at room temperature within 4 h and has a good functional group tolerance. The monofluoromethylating agent, CH2FI, was readily prepared via a halogen-exchange process.