Vascular health across young adulthood and midlife cerebral autoregulation, gait, and cognition.
Vascular health across young adulthood and midlife cerebral autoregulation, gait, and cognition.
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青年期和中年大脑自动调节、步态和认知的血管健康。
DOI：
10.1002/alz.12246
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Sorond,FarzanehA
中科院分区：
文献类型：
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作者：
Mahinrad,Simin;Shownkeen,Meghana;Sedaghat,Sanaz;Yaffe,Kristine;Hausdorff,JeffreyM;Lloyd-Jones,DonaldM;Gorelick,PhilipB;Sorond,FarzanehA
IntroductionTo测试与中年动态脑自动调节（dCA），步态和认知的血管健康（VH）在年轻的成年人之间的关联;并测试是否dCA是一个修改factor.MethodsWe研究了196名参与者的冠状动脉风险发展在年轻的成年人队列谁被随访超过30年。根据美国心脏协会的建议，在每次访视时评估VH。在第30年，dCA测量使用经颅多普勒超声和几个步态和认知领域进行了assessed.ResultsWorse VH从基线到7年，但不是在第30年，与效率较低的dCA（所有P < .05）。所有随访时VH越差，步态速度越慢，7年时执行和整体认知越差（均P <0.05）。基线VH和中年步态，但不认知的关联，是缓和dCA（interactionP<0.05）。结论早在年轻的成年VH可能会影响中年大脑健康，和dCA可能会改变这种关系。
IntroductionTo test the association of vascular health (VH) across young adulthood with midlife dynamic cerebral autoregulation (dCA), gait, and cognition; and to test whether dCA is a modifying factor.MethodsWe studied 196 participants from the Coronary Artery Risk Development in Young Adults cohort who were followed over 30 years. VH was assessed at each visit according to American Heart Association recommendations. At year 30, dCA was measured using transcranial Doppler ultrasound and several gait and cognitive domains were assessed.ResultsWorse VH from baseline through year 7, but not at year 30, was associated with less efficient dCA (allP< .05). Worse VH at all visits was associated with slower gait speed, and at year 7 with worse executive and global cognition (allP< .05). The association of baseline VH and midlife gait, but not cognition, was moderated by dCA (interactionP< .05).ConclusionsVH as early as young adulthood may influence midlife brain health, and dCA may modify this relationship.