Variations in maternal behaviour are associated with differences in oxytocin receptor levels in the rat
Variations in maternal behaviour are associated with differences in oxytocin receptor levels in the rat
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DOI：
10.1046/j.1365-2826.2000.00599.x
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发表时间：
2000-12-01
影响因子：
3.2
通讯作者：
Meaney, MJ
中科院分区：
文献类型：
--
作者：
Francis, DD;Champagne, FC;Meaney, MJ
雌性Long-Evans大鼠表现出稳定的母体行为，如幼崽舔/梳理和弓背护理姿势（LG-ABN）的个体差异。这些变化在母亲的行为是伴随着不同的哺乳期诱导的催产素受体水平的增加，在已知的大脑区域介导的表达在这个物种的孕产妇护理（即床核的终纹，内侧视前区和外侧隔）。无论生殖状态如何，高LG-ABN女性杏仁核中央核的催产素受体水平均显著高于低LG-ABN女性。这些研究结果表明，母亲行为的个体差异可能与催产素受体表达的变化直接相关。
Female Long-Evans rats exhibit stable individual differences in maternal behaviours such as pup licking/grooming and arched-back nursing posture (LG-ABN). These variations in maternal behaviour are accompanied by differences in lactation-induced increases in oxytocin receptor levels in brain regions known to mediate the expression of maternal care in this species (i.e. the bed nucleus of the stria terminalis, the medial preoptic area and the lateral septum). Oxytocin receptor levels in the central nucleus of the amygdala were significantly higher in high compared to low LG-ABN females regardless of reproductive status. These findings suggest that individual differences in maternal behaviour may be directly related to variations in oxytocin receptor expression.