Albumin catabolism in diabetic rats.
Albumin catabolism in diabetic rats.
复制标题
糖尿病大鼠的白蛋白分解代谢。
DOI：
10.1016/0003-9861(83)90028-0
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发表时间：
1983
影响因子：
3.9
通讯作者：
Thorpe,SR
中科院分区：
文献类型：
--
作者：
Murtiashaw,MH;Baynes,JW;Thorpe,SR
研究了正常大鼠和链脲佐菌素诱导糖尿病大鼠（血糖500mg %）白蛋白分解代谢动力学。无论是从血浆中清除125i白蛋白还是从全身清除125i白蛋白来确定，在严重的、不受控制的糖尿病10天后，与正常大鼠相比，糖尿病大鼠的白蛋白分解代谢率降低了30-35%。糖尿病大鼠的白蛋白相对血管外分布体积收缩约35%，白蛋白总质量减少约25%。然而，白蛋白在循环中的浓度在正常和糖尿病动物是相同的。我们得出结论，当糖尿病患者的白蛋白合成速率明显降低时，大鼠通过降低白蛋白的部分分解代谢速率和将白蛋白从血管外转移到血管室来维持正常的血浆白蛋白浓度。
The kinetics of albumin catabolism were studied in normal rats and rats with streptozotocin induced diabetes (blood glucose > 500 mg%). Whether determined from the clearance of125I-albumin from plasma or from the whole body, after 10 days of severe, uncontrolled diabetes there was a 30–35% decrease in the catabolic rate for albumin in the diabetic rats compared to normals. There was also about a 35% contraction of the relative extravascular distribution volume for albumin in the diabetic rats, and about a 25% decrease in the total body mass of albumin. However, the concentration of albumin in the circulation was the same in normal and diabetic animals. We conclude that when the rate of albumin synthesis is substantially depressed in diabetes, the rat maintains normal plasma albumin concentration both by decreasing albumin's fractional catabolic rate and by shifting albumin from the extravascular to the vascular compartment.