Hypothalamic response to starvation: implications for the study of wasting disorders.
Hypothalamic response to starvation: implications for the study of wasting disorders.
复制标题
下丘脑对饥饿的反应：对消耗性疾病研究的影响。
DOI：
10.1152/ajpregu.1995.269.5.r949
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Woods,SC
中科院分区：
文献类型：
--
作者：
Schwartz,MW;Dallman,MF;Woods,SC
体重减轻对正常人的食物摄入是一种有力的刺激。因此，消耗性疾病中厌食症的持续存在意味着这种适应性进食反应的失败。我们描述了一个模型的正常下丘脑对饥饿的反应，包括刺激的神经元通路，促进能量的摄入和存储加上抑制的途径，发挥相反的效果。该模型提供了一个框架，调查正常的下丘脑反应的体重减轻的障碍，并提出了一个特定的机制，细胞因子有助于获得性免疫缺陷综合征和其他恶病质疾病的浪费。
Weight loss is a potent stimulus to food intake in normal individuals. The persistence of anorexia in wasting disorders, therefore, implies a failure of this adaptive feeding response. We describe a model for the normal hypothalamic response to starvation composed of the stimulation of neuronal pathways that promote energy intake and storage coupled with the inhibition of pathways that exert opposing effects. This model provides a framework for investigating disturbances of the normal hypothalamic response to weight loss and suggests a specific mechanism by which cytokines contribute to wasting in acquired immune deficiency syndrome and other cachexic disorders.