Bioactive Silicate Nanoplatelets for Osteogenic Differentiation of Human Mesenchymal Stem Cells
Bioactive Silicate Nanoplatelets for Osteogenic Differentiation of Human Mesenchymal Stem Cells
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DOI：
10.1002/adma.201300584
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发表时间：
2013-06-25
影响因子：
29.4
通讯作者：
Khademhosseini, Ali
中科院分区：
文献类型：
--
作者：
Gaharwar, Akhilesh K.;Mihaila, Silvia M.;Khademhosseini, Ali
随着美国人口老龄化，伤害和退行性疾病的发生率随之增加。直接结果是，对能够修复受损组织和生产替代器官的疗法的需求增加。[1]特别是，非常需要能够指导干细胞分化并促进功能组织形成的新型生物活性材料。 [2]过去几年，已经报道了几种具有临床意义的用于肌肉骨骼组织工程的生物活性材料，包括生物活性玻璃(Na 2O–CaO–SiO 2–P2o 5)、羟基磷灰石(HA)(Ca 10 (PO 4) 6 (OH) 2)、β-磷酸三钙(TCP)(Ca 3 (PO 4) 2)、β-硅灰石(CaO-SiO) 2)、AW（磷灰石-硅灰石）玻璃陶瓷。[3]许多这些已知材料仍然存在的困难包括缺乏骨诱导特性、加工能力差和降解不充分。
With an aging US population, the occurrence of injuries and degenerative conditions are subsequently on the rise. As a direct result, there is an increase in demand for therapies that are able to repair damaged tissues and produce replacement organs.[1] In particular, there is a great need for new bioactive materials that can direct stem cell differentiation and facilitate the formation of functional tissues.[2] Several types of bioactive material that have clinical relevance have been reported for musculoskeletal tissue engineering in the last few years, including bioactive glasses (Na 2O–CaO–SiO 2–P2o 5), hydroxyapatite (HA)(Ca 10 (PO 4) 6 (OH) 2), β-tricalcium phosphate (TCP)(Ca 3 (PO 4) 2), β-wollastonite (CaO-SiO 2), and AW (Apatite-Wollastonite) glass ceramic.[3] Difficulties persisting with many of these known materials include lack of osteoinductive properties, poor processing abilities, and insufficient degradation.