Risks of harm with cannabinoids, cannabis, and cannabis-based medicine for pain management relevant to patients receiving pain treatment: protocol for an overview of systematic reviews.
Risks of harm with cannabinoids, cannabis, and cannabis-based medicine for pain management relevant to patients receiving pain treatment: protocol for an overview of systematic reviews.
复制标题
大麻素、大麻和以大麻为基础的药物用于与接受疼痛治疗的患者相关的疼痛管理的危害风险：系统评价概述的方案。
DOI：
10.1097/pr9.0000000000000742
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发表时间：
2019
期刊：
影响因子：
4.8
通讯作者：
Wallace,Mark
中科院分区：
文献类型：
--
作者：
Gilron,Ian;Blyth,FionaM;Degenhardt,Louisa;DiForti,Marta;Eccleston,Christopher;Haroutounian,Simon;Moore,Andrew;Rice,AndrewSC;Wallace,Mark
方法：本概述将涉及几个数据库的文献检索和定义的检索策略，该策略将针对大麻素的系统综述或荟萃分析，其中危害是主要焦点。数据提取将包括大麻素的各种特征和正在研究的危害，以及每个纳入系统综述的其他方法学特征。将使用AMSTAR-2以及PRISMA伤害检查表的合规性评估每个纳入审查的方法质量。讨论：本方案定义的综述的广泛概述预计将综合现有的高质量危害证据，这将有助于告知有关使用大麻素进行疼痛管理的风险-受益考虑。
Methods:This overview will involve literature searches of several databases and a defined search strategy that will target systematic reviews or meta-analyses of cannabinoids where harms are the primary focus. Data extraction will include various features of the cannabinoid (s) and the harm (s) being studied as well as other methodological features of each included systematic review. Methodological quality of each included review will be assessed using AMSTAR-2 as well as compliance with the PRISMA harms checklist. Prospero registration pending.Discussion:The broad overview of reviews defined by this protocol is expected to synthesize available good quality evidence of harms that will help inform risk-benefit considerations about the use of cannabinoids for pain management.