Genetic analyses of photopigment biosynthesis in eubacteria: a guiding light for algae and plants.
Genetic analyses of photopigment biosynthesis in eubacteria: a guiding light for algae and plants.
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真细菌感光色素生物合成的遗传分析：藻类和植物的指路明灯。
DOI：
10.1128/jb.175.13.3919-3925.1993
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发表时间：
1993
影响因子：
3.2
通讯作者：
Suzuki,JY
中科院分区：
文献类型：
--
作者：
Bauer,CE;Bollivar,DW;Suzuki,JY
各种各样的大环四吡咯化合物是由细胞合成用于不同的细胞过程。如图1所示，该途径包括含金属的封闭四吡咯化合物的合成，如含钴钴胺素（维生素B12）、含镍甲烷生成辅酶F430、含铜色素turacin、含铁血红素和siroheme、含镁叶绿素和细菌叶绿素。通过这一途径合成的还有各种开放的大环化合物，如在蓝藻、红藻和隐生植物中用作光收集色素来源的胆磷脂家族，以及在植物中共价附着在光敏色素载脂蛋白上的发色团。最近发表了几篇关于四吡咯生物合成途径各分支的生物化学和酶学的综合综述（6,22,51）。四吡咯生物合成途径的遗传分析是许多实验室研究的一个活跃领域。在过去的十年中，在获得5-氨基乙酰丙酸到血红素通路早期部分所涉及的位点的分子遗传信息方面取得了重大进展（33）。参与维生素B12合成的基因座也在分子遗传水平上被表征（33）。然而，生物合成途径中涉及mg -四吡咯分支的位点的分子遗传信息直到最近才获得。这篇小型综述将涵盖后一个领域，特别是最近使用细菌序列信息来帮助定义植物和藻类系统中类似位点的作用和进化关系。
A wide variety of macrocyclic tetrapyrrole compounds are synthesized by cells foruse in diverse cellular processes. As shown in Fig. 1, this pathway includes the synthesis of closed tetrapyrrole compounds that contain metals, such as cobalt-containing cobalamin (vitamin B12), nickel-containing methanogenesis coenzyme F430, copper-containing pigment turacin, iron-containing heme and siroheme, andmagnesium-containing chlorophylls and bacteriochlorophylls. Also synthesized by this pathway are a variety of open macrocyclic compounds such as the family of bilins that are used as a source of light-harvesting pigments in cyanobacteria, red algae, and cryptophytes as well as the chromophore that is covalently attached to phytochrome apoproteins in plants. Several comprehensive reviews which focus on the bio-chemistry and enzymology of the various branches of the tetrapyrrole biosynthetic pathway have recently been published (6, 22, 51). Genetic analysis of the tetrapyrrole biosynthesis pathway is an active area of study in a number of laboratories. Over the past decade, there has been significant progress in obtaining molecular genetic information on lociinvolved in the early part of the pathway leading from 5-aminolevulinic acid to heme (33). Loci involved in vitamin B12 synthesis have also been characterized at the molecular genetic level (33). Molecular genetic information on loci involved in the Mg-tetrapyrrole branch of the biosynthesis pathway has, however, only recently been obtained. It is this latter area that this minireview will cover, particularly the recent use of bacterial sequence information to aid in defining the roles and evolutionaryrelationships of similar loci from plant and algal systems.