Effectiveness of autologous preparation rich in growth factors for the treatment of chronic cutaneous ulcers
Effectiveness of autologous preparation rich in growth factors for the treatment of chronic cutaneous ulcers
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DOI：
10.1002/jbm.b.30886
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发表时间：
2008-02-01
影响因子：
3.4
通讯作者：
Andia, Isabel
中科院分区：
文献类型：
--
作者：
Anitua, Eduardo;Aguirre, Jose J.;Andia, Isabel
富含生长因子（PRGF）的自体制剂是一种富含血小板的小体积血浆，由于持续释放多种生长因子（包括PDGF-AB、TGF-β 1、IGF-I、HGF、VEGF-A和EGF），因此是用于加速广泛组织的伤口愈合的新型治疗策略。在这篇文章中，我们的特点PRGF制剂，并设计了一个随机开放标签对照试验，以评估PRGF在治疗慢性皮肤溃疡的有效性。结果显示，8周时，PRGF组的平均表面愈合百分比为72.94% ± 22.25%，而对照组为21.48% ± 33.56%（P < 0.05）。这些结果，与试点研究的局限性，表明局部应用PRGF是更有效的比标准治疗，帮助慢性溃疡愈合。(C)2007 Wiley Periodicals，Inc.
Autologous Preparation Rich in Growth Factors (PRGF), a small volume of plasma enriched in platelets, is a novel therapeutic strategy for the acceleration of the wound healing of a wide range of tissues because of the continuous release of multiple growth factors, including PDGF-AB, TGF-beta 1, IGF-I, HGF, VEGF-A, and EGF. In this article, we have characterized the PRGF preparation and designed a randomized open-label controlled pilot trial to evaluate the effectiveness of PRGF in the treatment of chronic cutaneous Ulcers. Results showed that at 8 weeks, the mean percentage of surface healed in the PRGF group was 72.94% +/- 22.25% whereas it was 21.48% +/- 33.56% in the control group (P < 0.05). These results, with the limitations of a pilot study, suggest that topical application of PRGF is more effective than standard therapy in helping a chronic ulcer to heal. (C) 2007 Wiley Periodicals, Inc.