Local adaptation and vector-mediated population structure in Plasmodium vivax malaria
Local adaptation and vector-mediated population structure in Plasmodium vivax malaria
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DOI：
10.1093/molbev/msn073
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发表时间：
2008-06-01
影响因子：
10.7
通讯作者：
Su, Xin-zhuan
中科院分区：
文献类型：
--
作者：
Joy, Deirdre A.;Gonzalez-Ceron, Lilia;Su, Xin-zhuan
墨西哥南部的间日疟原虫对当地的2种蚊媒--伪斑翅按蚊和白纹按蚊表现出不同的感染力。先前的研究将蚊子感染性的这些差异与疟原虫环子孢子（csp）基因中央重复序列的变异联系起来，但随后的研究对这一观点提出了质疑。在这里，我们提出的证据表明，在墨西哥南部的间日疟原虫包括3个遗传种群，其分布在很大程度上反映了2蚊子载体。此外，实验室群体喂养实验表明，寄生虫种群与同域蚊子物种最相容。我们的研究结果表明，疟疾寄生虫和蚊子媒介之间的相互选择，导致当地适应的寄生虫。适应当地媒介可能在疟原虫种群结构的形成中发挥重要作用。更好地了解同域蚊子和寄生虫之间的共同进化动力学将有助于确定自然界中疾病传播的分子机制，并为疟疾控制提供重要信息。
Plasmodium vivax in southern Mexico exhibits different infectivities to 2 local mosquito vectors, Anopheles pseudopunctipennis and Anopheles albimanus. Previous work has tied these differences in mosquito infectivity to variation in the central repeat motif of the malaria parasite's circumsporozoite (csp) gene, but subsequent studies have questioned this view. Here we present evidence that P. vivax in southern Mexico comprised 3 genetic populations whose distributions largely mirror those of the 2 mosquito vectors. Additionally, laboratory colony feeding experiments indicate that parasite populations are most compatible with sympatric mosquito species. Our results suggest that reciprocal selection between malaria parasites and mosquito vectors has led to local adaptation of the parasite. Adaptation to local vectors may play an important role in generating population structure in Plasmodium. A better understanding of coevolutionary dynamics between sympatric mosquitoes and parasites will facilitate the identification of molecular mechanisms relevant to disease transmission in nature and provide crucial information for malaria control.