FIBROBLASTS CREATE COMPARTMENTS IN THE EXTRACELLULAR-SPACE WHERE COLLAGEN POLYMERIZES INTO FIBRILS AND FIBRILS ASSOCIATE INTO BUNDLES
FIBROBLASTS CREATE COMPARTMENTS IN THE EXTRACELLULAR-SPACE WHERE COLLAGEN POLYMERIZES INTO FIBRILS AND FIBRILS ASSOCIATE INTO BUNDLES
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DOI：
10.1111/j.1749-6632.1985.tb51173.x
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发表时间：
1985-12-30
影响因子：
5.2
通讯作者：
TRELSTAD, RL
中科院分区：
文献类型：
--
作者：
BIRK, DE;TRELSTAD, RL
形态发生是一个复杂的过程，涉及基质组分之间的相互作用（基质-基质），基质和细胞之间的相互作用（基质-细胞），以及细胞本身之间的相互作用（细胞-细胞）。在这些相互作用的一般类别中，分子水平上的机制可能非常相似。例如，当透明质酸盐在细胞外空间中相对自由时，其与自身的相互作用在分子相互作用方面可能非常类似于透明质酸盐在细胞与细胞相互作用中结合到相对细胞的细胞表面的那些相互作用。同样，细胞与其基质的相互作用，如当细胞表面的纤连蛋白与基质定位的胶原蛋白相互作用时，在分子方面可能与在没有细胞的情况下发生的纤连蛋白和胶原蛋白的相互作用非常相似。调节胶原、蛋白多糖、弹性蛋白和糖蛋白所呈现的无数聚集形式的因子来自分子内、分子间和分子外力。分子内力由大分子固有的分子性质产生，其由氨基酸和相关碳水化合物侧链的顺序排列决定。这些分子内性质是分子大小和形状的主要决定因素，并与遗传信息密切相关。分子间缔合力来源于分子的大小、形状、电荷和疏水性质。分子间的相互作用也可能涉及酶促加工，从而导致尺寸、形状、电荷
Morphogenesis is a complex process involving interactions between matrix components (matrix-matrix), interactions between matrix and cells (matrix-cell), and interactions between cells themselves (cell-cell). In each of these general categories of interactions, the mechanisms at a molecular level might be quite similar. For example, the interactions of hyaluronate with itself when relatively free in the extracellular space may be quite similar, in molecular interaction terms, to those interactions of hyaluronate bound to the cell surfaces of opposed cells in a cell-to-cell interaction.’In like manner, the interactions of cells with their substratum, as when fibronectin on the cell surface interacts with substrate-localized collagen, may be quite similar in molecular terms to those interactions of fibronectin and collagen which occur in the absence of cells?The factors which regulate the myriad aggregated forms assumed by the collagens, proteoglycans, elastin, and glycoproteins derive from intramolecular, intermolecular, and extramolecular forces. The intramolecular forces result from molecular properties intrinsic to the macromolecule which are dictated by the sequential arrangement of amino acids and associated carbohydrate side chains. These intramolecular properties are the principal determinants of molecular size and shape and can be closely related to genetic information. Intermolecular associative forces derive from the size, shape, charge, and hydrophobic properties of the molecules. Intermolecular interactions may also involve enzymatic processing with consequent changes in the size, shape, charge