Bimodal Imaging Using Neodymium Doped Gadolinium Fluoride Nanocrystals with Near-Infrared to Near-Infrared Downconversion Luminescence and Magnetic Resonance Properties.
Bimodal Imaging Using Neodymium Doped Gadolinium Fluoride Nanocrystals with Near-Infrared to Near-Infrared Downconversion Luminescence and Magnetic Resonance Properties.
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DOI：
10.1039/c3tb20905a
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发表时间：
2013-11-07
期刊：
影响因子：
--
通讯作者：
Sardar DK
中科院分区：
文献类型：
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作者：
Mimun LC;Ajithkumar G;Pokhrel M;Yust BG;Elliott ZG;Pedraza F;Dhanale A;Tang L;Lin AL;Dravid VP;Sardar DK
在这里，我们报告的合成，表征和应用的多功能表面功能化的GdF 3：Nd 3+纳米荧光粉，表现出有效的近红外（NIR）荧光以及磁性能，可用于医疗应用中的双峰成像。纳米颗粒很小，平均尺寸为5 nm，形成稳定的胶体，可持续数周而不沉降，可用于多种生物医学和光子应用。其优异的NIR特性，例如1064 nm发射的近11%量子产率，使其成为体外和体内NIR光学生物成像的理想造影剂和生物标志物。用聚（马来酸酐- alt-1-辛二烯）（PMAO）涂覆的纳米磷光体在细胞成像中实施，并且在高达200 μg ml-1的浓度下没有显示出显著的细胞毒性。此外，将Gd掺入纳米晶结构提供了优异的磁性能，使其成为磁共振成像（MRI）造影剂的理想选择。这些近红外发射纳米粒子在红外生物成像和磁共振成像中作为对比剂的效用通过共聚焦成像、磁共振和组织实验证明。
Here we report the synthesis, characterization and application of a multifunctional surface functionalized GdF3:Nd3+ nanophosphor that exhibits efficient near infrared (NIR) fluorescence as well as magnetic properties, which can be utilized for bimodal imaging in medical applications. The nanoparticles are small with an average size of 5 nm and form stable colloids that last for several weeks without settling, enabling the use for several biomedical and photonic applications. Their excellent NIR properties, such as nearly 11 % quantum yield of the 1064 nm emission, make them ideal contrast agents and biomarkers for in vitro and in vivo NIR optical bioimaging. The nanophosphors which were coated with poly(maleic anhydride- alt-1-octadicene) (PMAO) were implemented in cellular imaging and show no significant cellular toxicity for concentrations up to 200 μg ml−1. Furthermore, the incorporation of Gd into the nanocrystalline structure supplies exceptional magnetic properties, making them ideal for use as magnetic resonance imaging (MRI) contrast agents. The utility of these NIR emitting nanoparticles in infrared bioimaging and as contrast agent in magnetic resonance imaging was demonstrated by confocal imaging, magnetic resonance and tissue experiments.