OSTEOSARCOMA OF THE PELVIS - A CLINICAL AND HISTOPATHOLOGICAL STUDY OF 25 PATIENTS
OSTEOSARCOMA OF THE PELVIS - A CLINICAL AND HISTOPATHOLOGICAL STUDY OF 25 PATIENTS
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DOI：
10.2106/00004623-199274030-00002
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发表时间：
1992-03-01
影响因子：
5.3
通讯作者：
VANDERGRIEND, RA
中科院分区：
文献类型：
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作者：
FAHEY, M;SPANIER, SS;VANDERGRIEND, RA
1967年至1990年间，佛罗里达大学对25例骨盆骨肉瘤患者进行了治疗。其中2名患者有潜在的佩吉特病，5名患者之前接受过骨盆放射治疗。该系列患者的常见问题包括诊断的延迟和错误，在影像学分期研究中低估肿瘤的范围，组织病理学发现局部扩展到盆腔结构附近并进入盆腔结构，广泛侵入盆腔主要静脉，显微镜下肿瘤病灶出现在其他正常组织中。这些问题导致难以获得肿瘤的局部控制与任何类型的手术程序。在18例切除的患者中，只有4例有无污染的宽边缘，13例出现局部复发。在撰写本文时，只有一名在治疗11年后没有任何疾病迹象的患者还活着。由于有静脉侵犯的倾向，x线分期研究应包括对肿瘤附近血管的全面评估。
Twenty-five patients who had an osteosarcoma of the pelvis were treated at the University of Florida between 1967 and 1990. Two of these patients had underlying Paget disease, and five had received previous radiation therapy to the pelvis. Common problems in this series of patients included delays and errors in establishment of the diagnosis, underestimation of the extent of the tumor on the radiographic staging studies, histopathological findings of local extension next to and into pelvic structures, widespread invasion into major pelvic veins, and microscopic foci of tumor in otherwise normal tissue. These problems led to difficulty in gaining local control of the tumor with any type of operative procedure. Of the eighteen patients who had a resection, only four had a contamination-free wide margin, and a local recurrence developed in thirteen. Only one patient, who had no evidence of disease eleven years after treatment, was alive at the time of writing. Because of the tendency for venous invasion, the radiographic staging studies should include a thorough evaluation of the blood vessels adjacent to the tumor.