Pregnancy and susceptibility to infectious diseases.
Pregnancy and susceptibility to infectious diseases.
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DOI：
10.1155/2013/752852
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发表时间：
2013
影响因子：
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通讯作者：
Kourtis AP
中科院分区：
文献类型：
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作者：
Sappenfield E;Jamieson DJ;Kourtis AP
为了总结关于孕妇对传染病的易感性和所导致疾病的严重程度的文献，我们使用PubMed搜索和其他策略进行了综述。如果研究报告了孕妇感染风险或疾病结局的信息，则纳入研究。共审查了1454篇摘要，共纳入85项研究。提取了有关孕妇病例数、感染率、疾病严重程度或并发症的风险因素以及孕产妇结局的数据。证据表明，怀孕与某些传染病的严重程度增加有关，如流感、疟疾、戊型肝炎和单纯疱疹病毒（HSV）感染（传播/肝炎风险）;也有一些证据表明麻疹和天花的严重程度增加。疾病的严重程度似乎更高与晚期妊娠。孕妇可能更容易感染疟疾、艾滋病毒感染和艾滋病，尽管证据有限。这些结果加强了感染预防以及早期发现和治疗疑似流感，疟疾，戊型肝炎和HSV疾病的重要性。
To summarize the literature regarding susceptibility of pregnant women to infectious diseases and severity of resulting disease, we conducted a review using a PubMed search and other strategies. Studies were included if they reported information on infection risk or disease outcome in pregnant women. In all, 1454 abstracts were reviewed, and a total of 85 studies were included. Data were extracted regarding number of cases in pregnant women, rates of infection, risk factors for disease severity or complications, and maternal outcomes. The evidence indicates that pregnancy is associated with increased severity of some infectious diseases, such as influenza, malaria, hepatitis E, and herpes simplex virus (HSV) infection (risk for dissemination/hepatitis); there is also some evidence for increased severity of measles and smallpox. Disease severity seems higher with advanced pregnancy. Pregnant women may be more susceptible to acquisition of malaria, HIV infection, and listeriosis, although the evidence is limited. These results reinforce the importance of infection prevention as well as of early identification and treatment of suspected influenza, malaria, hepatitis E, and HSV disease during pregnancy.