RADIATION MYELOPATHY IN PRIMATES TREATED WITH CONVENTIONAL FRACTIONATION
RADIATION MYELOPATHY IN PRIMATES TREATED WITH CONVENTIONAL FRACTIONATION
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DOI：
10.1016/0360-3016(90)90015-c
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发表时间：
1990-10-01
影响因子：
7
通讯作者：
PETERS, LJ
中科院分区：
文献类型：
--
作者：
SCHULTHEISS, TE;STEPHENS, LC;PETERS, LJ
用恒河猴模型测定脊髓对~(60)Co照射的耐受性，剂量为2.2Gy.D50为76.1Gy.(扫描电子显微镜=1.9Gy.)，1%和0.1%脊髓病的估算剂量为59.1+-。5.5Gy52.1.+-。治疗剂量分别为7.1Gy.潜伏期为5~20个月，随剂量增加潜伏期缩短。所有有症状的动物都有涉及主要运动束的白质实质损害，大多数也有白质血管损害。无症状动物的脊髓要么没有组织病理学改变，要么有不涉及运动束的小白质损害。
A rhesus monkey model was used to assay the radiation tolerance of the spinal cord to 60Co radiation given in 2.2 Gy fractions. The D50 was found to be 76.1 Gy (SEM = 1.9 Gy); the estimated doses for 1% and 0.1% myelopathy were 59.1 .+-. 5.5 Gy and 52.1 .+-. 7.1 Gy, respectively. The latent period ranged from 5 to 20 months and decreased with increasing dose. All symptomatic animals had white-matter parenchymal lesions involving major motor tracts, and most also had vascular lesions in the white matter. Spinal cords of asymptomatic animals had either no histopathologic changes or small white-matter lesions that did not involve motor tracts.