DOSE-RESPONSE RELATIONSHIP BETWEEN LIGHT IRRADIANCE AND THE SUPPRESSION OF PLASMA MELATONIN IN HUMAN VOLUNTEERS
DOSE-RESPONSE RELATIONSHIP BETWEEN LIGHT IRRADIANCE AND THE SUPPRESSION OF PLASMA MELATONIN IN HUMAN VOLUNTEERS
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DOI：
10.1016/0006-8993(88)90820-7
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发表时间：
1988-06-28
期刊：
影响因子：
2.9
通讯作者：
HUDSON, D
中科院分区：
文献类型：
--
作者：
BRAINARD, GC;LEWY, AJ;HUDSON, D
这项研究测试了不同照射强度的单色光降低正常人血浆褪黑激素的能力。6名健康男性志愿者，年龄24-34岁，分别在夜间暴露于0.01W/cm2、0.3W/cm2、1.6W/cm2、5W/cm2和13μW/cm2的509 nm单色光1h。光照对血浆褪黑素的抑制作用呈剂量-反应关系。数据表明，抑制褪黑素的平均阈值辐照度在1.6W/cm~2~5μW/cm~2之间。在志愿者中观察到对单色光的阈值反应的个体差异。
This study tested the capacity of different irradiances of monochromatic light to reduce plasma melatonin in normal humans. Six healthy male volunteers, 24–34 years old, were exposed to 0.01, 0.3, 1.6,5, or 13 μW/cm2of 509 nm monochromatic light for 1 h during the night on separate occasions. Light irradiance depressed plasma melatonin in a dose-response pattern. The data indicate that the mean threshold irradiance for suppressing melatonin is between 1.6 and 5μW/cm2. Individual variations in threshold responses to monochromatic light were observed among the volunteers.