Prevalence of sleep-disordered breathing in a 316-patient French cohort of stable congestive heart failure
Prevalence of sleep-disordered breathing in a 316-patient French cohort of stable congestive heart failure
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DOI：
10.1016/j.acvd.2008.12.006
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发表时间：
2009-03-01
影响因子：
3
通讯作者：
d'Ortho, Marie-Pia
中科院分区：
文献类型：
--
作者：
Paulino, Alexandra;Damy, Thibaud;d'Ortho, Marie-Pia
背景资料。-心力衰竭合并收缩功能障碍频繁发生。北美和德国的研究表明，心力衰竭患者中陡峭呼吸障碍的发生率很高。-评估法国心力衰竭患者睡眠呼吸障碍的患病率及其相关危险因素。-共有316名稳定性心力衰竭患者和左心室射血分数小于或等于45%的患者接受了多导血管造影，以前瞻性地诊断重度呼吸暂停综合征，定义为呼吸暂停-低呼吸指数大于或等于10次/小时。平均年龄59±13岁，左心室射血分数30±11%，体重指数28±6 kg/m(2)。急促呼吸障碍的发生率为81%(n=256)；30%的综合征属于中枢，70%的综合征属于阻塞性。平均呼吸暂停低通气指数较高(30+/-3次/小时)，大部分(41%)呼吸暂停低通气指数大于或等于30次/小时。中枢性睡眠呼吸暂停综合征与更严重的心力衰竭和更高的呼吸暂停低通气指数相关。女性陡度呼吸紊乱的发生率低于男性(为85%；XI(2)=0.0003)，其严重程度(平均呼吸暂停-低通气指数为15+/-13次/小时比27+/-19次/小时，P=0.0001)。-在法国心力衰竭人群中，陡峭呼吸障碍的患病率很高，大多数综合征都有梗阻模式。男性的患病率和严重程度高于女性。(C)2009年爱思唯尔·马森公司。版权所有。
Background. - Heart failure with systolic dysfunction occurs frequently. Studies in North America and Germany have shown a high prevalence of steep-disordered breathing in patients with heart failure.Aims. - To assess the prevalence of sleep-disordered breathing and its associated risk factors in French patients with heart failure.Methods. - A total of 316 patients with stable heart failure and a left ventricular ejection fraction less or equal to 45% underwent polygraphy prospectively to diagnose steep apnoea syndrome, defined as an apnoea-hypopnoea index greater or equal to 10events/h.Results. - Mean age, left ventricular ejection fraction, and body mass index were 59 +/- 13 years, 30 +/- 11% and 28 +/- 6kg/m(2), respectively. The prevalence of steep breathing disorder was 81% (n = 256); 30% of syndromes were classified as central and 70% as obstructive. The mean apnoea-hypopnoea index was high (30 +/- 3 events/h) and a large proportion (41%) of syndromes had an apnoea-hypopnoea index greater or equal to 30 events/h. A central sleep apnoea syndrome pattern was associated with more severe heart failure and a more elevated apnoea-hypopnoea index than an obstructive pattern. The prevalence of steep-disordered breathing was lower in women than in men (64% versus 85%; chi(2) = 0.0003) as was its severity (mean apnoea-hypopnoea index 15 +/- 13 events/h versus 27 +/- 19 events/h, p = 0.0001).Conclusion. - The prevalence of steep-disordered breathing was high in a French heart failure population, with most syndromes having an obstructive pattern. Prevalence and severity were higher in men than in women. (C) 2009 Elsevier Masson SAS. All rights reserved.