Association of the asporin D14 allele with lumbar-disc degeneration in Asians
Association of the asporin D14 allele with lumbar-disc degeneration in Asians
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DOI：
10.1016/j.ajhg.2007.12.017
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发表时间：
2008-03-01
影响因子：
9.8
通讯作者：
Chan, Danny
中科院分区：
文献类型：
--
作者：
Song, You-Qiang;Cheung, Kenneth M. C.;Chan, Danny
腰椎间盘退变（LDD）是一种多基因疾病。目前报道的易感基因主要是细胞外基质蛋白。阿孢菌素 (ASPN) 的 D14 等位基因与骨关节炎 (OA) 相关。候选基因关联研究表明，D14 等位基因也与中国和日本个体的 LDD 显着相关。荟萃分析显示，携带 D14 等位基因的个体风险较高，总比值比为 1.70 (p = 0.000013)。椎间盘中 ASPN 的表达随着年龄和退变而增加。我们的结果表明 ASPN 是亚洲人的 LDD 基因，并且 OA 和 LDD 可以考虑常见的危险因素。
Lumbar-disc degeneration (LDD) is a polygenic disease. Susceptibility genes reported so far are mainly extracellular matrix proteins. D14 allele of asporin (ASPN) is associated with osteoarthritis (OA). Candidate-gene association studies showed that the D14 allele is also significantly associated with LDD in Chinese and Japanese individuals. Meta-analysis showed that individuals harboring a D14 allele had higher risk with a summary odds ratio of 1.70 (p = 0.000013). ASPN expression in vertebral discs increased with age and degeneration. Our results indicate ASPN is a LDD gene in Asians, and common risk factors may be considered for OA and LDD.