Serum levels of human β-defensin 2: possible association with fibrosis and vasculopathy in patients with systemic sclerosis.
Serum levels of human β-defensin 2: possible association with fibrosis and vasculopathy in patients with systemic sclerosis.
复制标题
人β-防御素2的血清水平：可能与系统性硬化症患者的纤维化和血管病变相关。
DOI：
10.1111/jdv.15546
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Sato S.
中科院分区：
文献类型：
--
作者：
Kuzumi A;Yoshizaki A;Fukasawa T;Ebata S;Miura S;Yoshizaki A;Sumida H;Asano Y;Sato S.
系统性硬化症（SSc）是一种自身免疫性疾病，其特征是皮肤和内脏的血管病变和纤维化1。人β-防御素2（HBD-2）是最早从银屑病鳞屑2中分离得到的一种抗菌肽。除了抗微生物活性，HBD-2还涉及免疫反应3和血管生成4，并与自身免疫性疾病如系统性红斑狼疮5有关
Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy and fibrosis of the skin and internal organs 1. Human β-defensin 2 (HBD-2) is an antimicrobial peptide that was first isolated from psoriatic scales 2. Apart from antimicrobial activities, HBD-2 is also implicated in immune responses 3 and angiogenesis 4, and has been associated with autoimmune diseases like systemic lupus erythematosus 5