Changes in serum levels of biochemical markers of bone turnover during 10 years among Japanese men and women : associated factors and birth-cohort effect : The Taiji Study
Changes in serum levels of biochemical markers of bone turnover during 10 years among Japanese men and women : associated factors and birth-cohort effect : The Taiji Study
复制标题
日本男性和女性 10 年来骨转换生化标志物血清水平的变化：相关因素和出生队列效应：太极研究
DOI：
10.1007/s00774-011-0266-8
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发表时间：
2011
影响因子：
3.3
通讯作者：
et al
中科院分区：
文献类型：
--
作者：
Yoshimura N;et al
我们的目的是阐明日本社区10年来骨转换生化标志物（BTM）的变化、与骨矿物质密度（BMD）变化的相关性以及出生队列效应。我们从1993年登记的居民名单中随机选择了400人（年龄，40-79岁;每个性别和年龄层50人）。在1993年和2003年，我们测量了脊柱和髋关节的BMD，以及总骨钙素（OC）、I型胶原的β-C-末端交联端肽（β-CTX）和I型胶原的N-末端交联端肽（NTX）的血清浓度。在400例受试者中，322例（153例男性，169例女性）完成了10年随访。平均变化率10年内血清总OC、β-CTX和NTX的标准差为-1.00（3.74）%/年，5.10（22.48）%/年和0.40（3.41）%/年，女性分别为0.02（5.32）%/年、5.53（14.54）%/年和0.62（3.26）%/年。40岁组BTM变化率高于50 ~ 70岁组（P< 0.05），月经过渡组高于绝经前后组（P< 0.001）。在调整潜在混杂因素后，女性10年内BTM水平的变化与L2-L4和全髋BMD的变化率显著相关。在50多岁的女性中观察到了显著的出生队列效应。我们得出的结论是，10年间BTM的变化率受到月经过渡、年龄和性别的影响，并与L2-L4和全髋关节的骨质流失相关。
We aimed to clarify changes in biochemical markers of bone turnover (BTMs) over 10 years, associations with changes in bone mineral density (BMD), and birth-cohort effects in a Japanese community. We randomly selected 400 individuals (age, 40–79 years; 50 of each gender and age stratum) from a list of registered residents in 1993. We measured BMD of the spine and hip, and serum concentrations of total osteocalcin (OC), beta-C-terminal cross-linking telopeptide of type I collagen (beta-CTX), and N-terminal cross-linking telopeptide of type I collagen (NTX), in 1993 and 2003. Of the 400 subjects, 322 (153 men, 169 women) completed the 10-year follow-up. Mean change rates (standard deviation) for serum total OC, beta-CTX, and NTX over 10 years were –1.00 (3.74)%/year, 5.10 (22.48)%/year, and 0.40 (3.41)%/year, respectively, in men, and 0.02 (5.32)%/year, 5.53 (14.54)%/year, and 0.62 (3.26)%/year, respectively, in women. Change rates of BTMs were higher for women in their forties than for women in their fifties to seventies (P< 0.05), and higher in the menstrual transition group than in pre- and postmenopausal groups (P< 0.001). Changes in levels of BTMs over 10 years in women were significantly associated with change rates of BMDs at L2–L4 and total hip after adjusting for potential confounders. A significant birth-cohort effect was observed among women in their fifties. We concluded that change rates of BTMs during the 10 years were influenced by menstrual transition, age, and sex and associated with bone loss at L2–L4 and total hip.