Is attrition bias a problem in neonatal follow-up?
Is attrition bias a problem in neonatal follow-up?
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DOI：
10.1016/j.earlhumdev.2005.07.006
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发表时间：
2005-11-01
影响因子：
2.5
通讯作者：
Verloove-Vanhorick, S
中科院分区：
文献类型：
--
作者：
Hille, ETM;den Ouden, AL;Verloove-Vanhorick, S
目的：评估脱落率是否影响极早产儿随访结果。研究设计：1983年在荷兰进行的一项全国性的活产婴儿随访研究中，胎龄小于32周和/或出生体重小于1500 g，对14岁时对随访邀请早或晚作出反应的婴儿的结局进行了单独评估。通过单变量和名义变量，将早期和晚期应答者的早期评估的新生儿数据和结局结果与无应答者进行比较。受试者：有723例（76%）早期应答者，130例（14%）晚期应答者和109例（11%）无应答者。我们发现，在10岁时，非荷兰血统的人明显更多，残疾和学校问题更多，特别是在无反应者中。在14岁时，与早期应答者相比，晚期应答者的健康效用指数显著降低。学校的结果并没有表现出差异，在retation的响应groups.Conclusion：结果表明，不良后果的发生率在非常早产儿被低估时，后续是不完整的，因此响应率是一个不可忽视的问题，在评估后期的结果。因此，随访研究应包括脱落分析，以便与其他研究进行比较。(c)2005年由Elsevier爱尔兰有限公司出版
Aim: To assess whether attrition rate influences outcome in the follow-up of very preterm infants. Study design: In a national follow-up study of infants born alive in 1983 in the Netherlands with a gestational age less than 32 weeks and/or a birth weight less than 1500 g, outcome was assessed separately for adotescents who responded early or late to a follow-up invitation at age 14 years. Neonatal data and outcome results of earlier assessments from early and late responders were compared to those of non-responders by univariate and nominal (polytomous logistic) regression analysis.Subjects: There were 723 (76%) early responders, 130 (14%) late responders and 109 (11%) non-responders.Results: We found significantly more non-Dutch origin and more disabilities and school problems at age 10 years in late- and especially in non-responders. At age 14 years, the health utility index was significantly tower in late responders compared to early responders. School outcome did not show difference in retation to the response groups.Conclusion: The results suggest that the incidence of adverse outcome in very preterm infants is underestimated when follow-up is incomplete and hence response rate is not a negligible problem in the assessment of late outcome. Therefore, follow-up studies should include a drop-out analysis to enable comparison to other studies. (c) 2005 Published by Elsevier Ireland Ltd.