Lesions of dorsolateral striatum preserve outcome expectancy but disrupt habit formation in instrumental learning
Lesions of dorsolateral striatum preserve outcome expectancy but disrupt habit formation in instrumental learning
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DOI：
10.1111/j.1460-9568.2004.03095.x
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发表时间：
2004-01-01
影响因子：
3.4
通讯作者：
Balleine, BW
中科院分区：
文献类型：
--
作者：
Yin, HH;Knowlton, BJ;Balleine, BW
习惯是由之前的刺激控制的，而不是由目标预期控制的，反馈的间隔时间表已被证明可以产生习惯，正如在该时间表下获得的行为对结果贬值治疗的不敏感所揭示的那样。我们进行了两个实验来评估背外侧纹状体在习惯学习中的作用。在实验1中，假手术对照组和背外侧纹状体病变的大鼠被训练按间隔时间表按杠杆获取蔗糖。训练后，通过使用氯化锂诱导对蔗糖的味觉厌恶来降低蔗糖的价值，而对照组则接受生理盐水注射。只有给予贬值治疗的大鼠减少了蔗糖的消耗，这种减少在假药组和病变组都是相似的。然后，所有的大鼠都被送回仪器室进行熄灭测试，在这个测试中，杠杆被延长，但没有蔗糖被传递。与假手术对照组相比，背外侧纹状体病变的大鼠在结果贬值时不会按压杠杆。为了评估背外侧纹状体在这种作用中的作用的特异性，进行了第二次实验，其中加入了背内侧纹状体病变组。与假手术组和背外侧纹状体损伤组相比，只有背外侧纹状体损伤的大鼠在结果贬值后反应明显降低。总之，本研究提供了背外侧纹状体是习惯形成所必需的直接证据。此外，它还表明，当习惯系统被破坏时，对工具行为的控制就会回归到控制目标导向工具行为表现的系统。
Habits are controlled by antecedent stimuli rather than by goal expectancy Interval schedules of feedback have been shown to generate habits, as revealed by the insensitivity of behaviour acquired under this schedule to outcome devaluation treatments. Two experiments were conducted to assess the role of the dorsolateral striatum in habit learning. In Experiment 1, sham operated controls and rats with dorsolateral striatum lesions were trained to press a lever for sucrose under interval schedules. After training, the sucrose was devalued by inducing taste aversion to it using lithium chloride, whereas saline injections were given to the controls. Only rats given the devaluation treatment reduced their consumption of sucrose and this reduction was similar in both the sham and the lesioned groups. All rats were then returned to the instrumental chamber for an extinction test, in which the lever was extended but no sucrose was delivered. In contrast to sham operated controls, rats with dorsolateral striatum lesions refrained from pressing the lever if the outcome was devalued. To assess the specificity of the role of dorsolateral striatum in this effect a second experiment was conducted in which a group with lesions of dorsomedial striatum was added. In relation now to both the sham and the dorsomedial lesioned groups, only rats with lesions of dorsolateral striatum significantly reduced responding after outcome devaluation. In conclusion, this study provides direct evidence that the dorsolateral striatum is necessary for habit formation. Furthermore, it suggests that, when the habit system is disrupted, control over instrumental performance reverts to the system controlling the performance of goal-directed instrumental actions.