Hydrogen peroxide: a Jekyll and Hyde signalling molecule.
Hydrogen peroxide: a Jekyll and Hyde signalling molecule.
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DOI：
10.1038/cddis.2011.96
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发表时间：
2011-10-06
影响因子：
9
通讯作者：
中科院分区：
文献类型：
--
作者：
活性氧(ROS)是细胞内通过氧代谢产生的一组分子。长期以来，过氧化氢(H_2O_2)等内源性ROS一直被认为是破坏性分子。它们在吞噬小体和基因组不稳定中所扮演的角色已经确立，这导致了这些分子被定性为非特异性破坏剂。有趣的是，越来越多的文献表明，这个Jekyll和Hyde分子扮演着不那么险恶的角色。现在很明显，在较低的生理水平上，过氧化氢可以作为一种经典的细胞内信号分子来调节激酶驱动的通路。新发现的ROS的生物学功能包括增殖、迁移、失巢、存活和自噬。此外，最近在检测和定量ROS家族成员方面的进展表明，ROS的不同功能可以由这些分子在细胞内的亚细胞来源、位置和持续时间来决定。鉴于这一令人困惑的悖论，我们将研究决定过氧化氢的作用是有利于生存还是有害的因素和环境。
Reactive oxygen species (ROS) are a group of molecules produced in the cell through metabolism of oxygen. Endogenous ROS such as hydrogen peroxide (H2O2) have long been recognised as destructive molecules. The well-established roles they have in the phagosome and genomic instability has led to the characterisation of these molecules as non-specific agents of destruction. Interestingly, there is a growing body of literature suggesting a less sinister role for this Jekyll and Hyde molecule. It is now evident that at lower physiological levels, H2O2 can act as a classical intracellular signalling molecule regulating kinase-driven pathways. The newly discovered biological functions attributed to ROS include proliferation, migration, anoikis, survival and autophagy. Furthermore, recent advances in detection and quantification of ROS-family members have revealed that the diverse functions of ROS can be determined by the subcellular source, location and duration of these molecules within the cell. In light of this confounding paradox, we will examine the factors and circumstances that determine whether H2O2 acts in a pro-survival or deleterious manner.
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