Probing chemical reactions on the nanometer scale:: Inverted chemical force microscopy of reactive self-assembled monolayers
Probing chemical reactions on the nanometer scale:: Inverted chemical force microscopy of reactive self-assembled monolayers
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DOI：
10.1016/j.susc.2004.06.177
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发表时间：
2004-10-10
期刊：
影响因子：
1.9
通讯作者：
Vancso, GJ
中科院分区：
文献类型：
--
作者：
Dordi, B;Pickering, JP;Vancso, GJ
利用倒置化学力显微镜（iCFM）在纳米尺度上研究了11，11 '-二硫代双（N-羟基琥珀酰亚胺基十一酸酯）（NHS-C10）在金表面自组装单分子膜（SAM）上的水解和氨解过程.在iCFM中，反应物被固定在原子力显微镜尖端上，而不是在衬底上，并且在尖端的表面处发生的化学反应通过在惰性十八烷基硫醇覆盖的衬底上的力-位移测量来探测。所获得的信息仅限于拉脱时的接触面积，其数量级仅为几nm（2）。因此，相互作用和反应动力学可以在类似于10 -100个分子的水平上进行定量研究。特别是，iCFM数据显示，NHS-C-10的自组装膜上的氨解反应是空间非均相反应。另外，可以获得关于反应性SAM的缺陷密度的信息。(C)2004 Elsevier B. V.保留所有权利。
The hydrolysis and aminolysis of 11,11'-dithiobis(N-hydroxysuccinimidylundecanoate) (NHS-C 10) adsorbed as self-assembled monolayer (SAM) on gold surfaces were monitored on the nanometer scale by a novel approach termed "inverted" chemical force microscopy (iCFM). In iCFM the reactants are immobilized on an atomic force microscopy tip rather than on the substrate and the chemical reactions that take place at the surface of the tip are probed by force-displacement measurements on an inert octadecanethiol-covered An substrate. The information obtained is confined to the contact area at pull-off, which is of the order of only several nm(2). Thus interactions and hence reaction kinetics can be quantitatively studied on the level of similar to10-100 molecules. In particular, iCFM data show that the aminolysis reaction on SAMs of NHS-C-10 is a spatially heterogeneous reaction. In addition information about the defect density of reactive SAMs can be obtained. (C) 2004 Elsevier B.V. All rights reserved.