Regional homogeneity changes in heavy male smokers: a resting-state functional magnetic resonance imaging study
Regional homogeneity changes in heavy male smokers: a resting-state functional magnetic resonance imaging study
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DOI：
10.1111/j.1369-1600.2011.00359.x
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发表时间：
2013-07-01
影响因子：
3.4
通讯作者：
Lu, Lin
中科院分区：
文献类型：
--
作者：
Yu, Rongjun;Zhao, Liyan;Lu, Lin
最近的研究证明，慢性吸烟者的整体认知功能下降，任务相关的大脑激活异常。然而，长期大量吸烟对任务无关的基线大脑活动的影响仍然是未知的。在这里，我们使用了区域同质性（ReHo）的方法结合功能磁共振成像（fMRI），研究自发神经活动在静息状态下，在重度吸烟者。与对照组相比，重度吸烟者的前额叶ReHo降低，而后扣带回和后扣带回ReHo升高。我们的研究可能会更好地理解吸烟的神经生物学后果。
Recent studies have documented declined global cognitive function and abnormal task-related brain activation in chronic cigarette smokers. However, the effects of long-term heavy smoking on task-independent baseline brain activity are still unknown. Here, we used a regional homogeneity (ReHo) method combined with functional magnetic resonance imaging (fMRI) to investigate spontaneous neural activity in the resting state in heavy smokers. Compared with controls, heavy smokers exhibited decreased ReHo in prefrontal regions, as well as increased ReHo in insula and posterior cingulate cortex. Our study may better our understanding of the neurobiological consequences of smoking.