Influence of 5-HTR2A genetic polymorphisms on the efficacy of antidepressants in the treatment of major depressive disorder: A meta-analysis
Influence of 5-HTR2A genetic polymorphisms on the efficacy of antidepressants in the treatment of major depressive disorder: A meta-analysis
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DOI：
10.1016/j.jad.2014.06.012
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发表时间：
2014-10-15
影响因子：
6.6
通讯作者：
Chu, Yang
中科院分区：
文献类型：
--
作者：
Lin, Jian-Yang;Jiang, Ming-Yan;Chu, Yang
目的：探讨5-HTR2A基因常见遗传多态对抗抑郁药治疗抑郁症疗效的影响。方法：检索Medline(1966-2013)、Cochrane图书馆数据库(2013-12期)、EMBASE(1980-2013)、CINAHL(1982-2013)、Web of Science(1945-2013)和中国生物医学数据库(1982-2013)。采用STATA统计软件进行Meta分析。我们计算优势比(OR)及其95%可信区间(95%CI)来评估抗抑郁药物治疗MDD的疗效。结果：11项研究共1775名MDD患者符合本荟萃分析的纳入标准。结果表明，5-HTR2A基因rs6311C>；T、rs7997012G>；A和rs6313T>；C多态性与MDD患者对抗抑郁药物的有效率显著相关(等位基因模型：OR-133，95%CI=1.05-1.68，P=0.020；显性模型：OR=1.62，95%CI=1.21-218，P=0.001；纯合子模型：OR=1.85，95%CI=1.18-2.90，P=0.008)。在优势模式下，rs7997012G>；A基因多态性与MDD患者抗抑郁药物的有效率相关(OR-19295%CI=1.02~3.61，P=0.044)。结论：5-HTR2Ars6313T>；C和rs7997012G>；A基因多态性可能与抗抑郁药物治疗MDD的疗效相关。(C)2014爱思唯尔B.V.保留所有权利
Objective: The aim of the current meta-analysis was to assess the influence of common genetic polymorphisms in the 5-HTR2A gene on the efficacy of antidepressants in the treatment of major depressive disorder (MDD).Method: MEDLINE (1966-2013), Cochrane Library Database (Issue 12, 2013), EMBASE (1980-2013), CINAHL (1982-2013), Web of Science (1945-2013) and Chinese Biomedical Database (CBM) (1982-2013) were searched without language restrictions. Meta-analysis was performed using the STATA statistical software. We calculated the odds ratio (OR) and its 95% confidence interval (95% Cl) to estimate the efficacy of antidepressants in the treatment of MDD.Results: Eleven studies with a total of 1775 MDD patients met the inclusion criteria of this meta-analysis. Three common polymorphisms in the 5-HTR2A gene were assessed, including rs6311 C> T, rs7997012 G > A, and rs6313 T> C. Our findings suggested that the 5-HTR2A rs6313 T> C polymorphism was significantly correlated with a higher response rate to antidepressants in MDD patients (allele model: OR-133 95% CI=1.05-1.68, P=0.020; dominant model: OR=1.62, 95% CI=1.21-218, P=0.001; homozygous model: OR=1.85, 95% CI=1.18-2.90, P=0.008). The rs7997012 G > A polymorphism was also associated with a higher response rate to antidepressants in MDD patients under the dominant model (OR- 192 95% CI=1.02-3.61, P=0.044). However, no significant correlation was found for the 5-HTR2A rs6311 C> T polymorphism under five genetic models (all P> 0.05).Conclusion: Our findings provide empirical evidence that the 5-HTR2A rs6313 T > C and rs7997012 G > A polymorphism may be correlated with the efficacy of antidepressants in the treatment of MDD. (C) 2014 Elsevier B.V. All rights reserved