Resident bone marrow macrophages produce type 1 interferons that can selectively inhibit interleukin-7-driven growth of B lineage cells.
Resident bone marrow macrophages produce type 1 interferons that can selectively inhibit interleukin-7-driven growth of B lineage cells.
复制标题
DOI：
10.1016/1074-7613(95)90176-0
复制
发表时间：
1995-10
期刊：
影响因子：
32.4
通讯作者：
Jiyang Wang;Q. Lin;Heather Langston;Max D. Cooper
中科院分区：
文献类型：
--
作者：
Jiyang Wang;Q. Lin;Heather Langston;Max D. Cooper
1 型干扰素 a 和 R 被发现是 IL-7 诱导的早期 B 谱系细胞生长的有效抑制剂，同时对 IL-2、IL-3、IL-4 或自体因子诱导的细胞生长没有影响。 IL-7 和干扰素 α/β 的组合可诱导 bcl-2 下调并通过细胞凋亡导致细胞死亡。这些结论最初源自使用外源细胞因子的实验，但功能性 1 型干扰素也被证明是由常驻骨髓巨噬细胞产生的。作为 IL-7 驱动的增殖和细胞存活的生理调节剂，干扰素 α/β 可能与其他稳态因子协同维持正常 B 谱系细胞的平衡生产。
Type 1 interferons a and R are found to be potent inhibitors of IL-7-induced growth of early B lineage cells, while having no effect on cell growth induced by IL-2, IL-3, IL-4, or autogenous factors. The combination of IL-7 and interferons α/β induces bcl-2 down-regulation and cell death by apoptosis. These conclusions were derived initially from experiments employing exogenous cytokines, but functional type 1 interferons are also shown to be produced by resident bone marrow macrophages. As physiological modulators of IL-7-driven proliferation and cell survival, interferons α/β may cooperate with other homeostatic factors to maintain the balanced production of normal B lineage cells.