Is there a geographical variation in eczema prevalence in the UK? Evidence from the 1958 British birth cohort study
Is there a geographical variation in eczema prevalence in the UK? Evidence from the 1958 British birth cohort study
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DOI：
10.1046/j.1365-2133.2000.03416.x
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发表时间：
2000-04-01
影响因子：
10.3
通讯作者：
Strachan, DP
中科院分区：
文献类型：
--
作者：
McNally, NJ;Williams, HC;Strachan, DP
一些研究表明，特应性湿疹的患病率可能因地理区域而异。这项描述性研究调查了7岁时报告和检查的湿疹患病率的区域和次区域地理。使用1958年出生队列研究（n = 828）的数据在英国11和16岁。计算了与居住在该国每个地区相关的湿疹报告的相对风险估计值，并比较了报告和检查的湿疹患病率的地区分布。报告的湿疹患病率分布在较小的县一级。与哮喘和花粉热患病率的县级分布进行了比较。这项研究显示，英国各地区湿疹患病率存在显著的统计学差异，这在检查和报告湿疹时都存在。风险最高的是四个地区：北米德兰兹;东部;伦敦和东南部;南部。在调整社会阶层和家庭规模后，这种区域模式没有明显改变。在县一级分析时，湿疹患病率的地理分布基本保持不变。湿疹患病率的县级分布与哮喘和花粉热的分布之间几乎没有相似之处，现在需要从环境和生活方式的角度来寻求这种强烈的区域差异的解释。
Some studies have suggested that the prevalence of atopic eczema may vary between geographical regions. This descriptive study investigates the regional and subregional geography of reported and examined eczema prevalence at the age of 7. 11 and 16 years in Britain using data from the 1958 birth cohort study (n = 828). Estimates of the relative risk of reported eczema associated with residence in each region of the country were calculated and the regional distribution of reported and examined eczema prevalence was compared. The reported prevalence of eczema was mapped at the smaller county level. Comparisons were made with the county-level distribution of asthma and hay fever prevalence. The study showed a marked and statistically significant variation in eczema prevalence across the regions in Britain which was present for examined as well as reported eczema. The highest risk was associated with four regions: North Midlands; Eastern; London and the South-East; and Southern. This regional pattern was not altered significantly after adjustment for social class and family size. The geographical distribution of eczema prevalence was largely maintained when analysed at the county level. Few similarities were found between the county-level distribution of eczema prevalence and that for asthma and hay fever, Explanations for this strong regional variation now need to be sought in terms of environmental and life-style associations.