Bacterial Pathogens Causing Pneumonia Post Hematopoietic Stem Cell Transplant: The Chronic GVHD Population.

Bacterial Pathogens Causing Pneumonia Post Hematopoietic Stem Cell Transplant: The Chronic GVHD Population.
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DOI:
10.3390/pathogens12050726
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发表时间:
2023-05-17
期刊:
Pathogens (Basel, Switzerland)
影响因子:
--
通讯作者:
Sadikot RT
Sadikot RT
中科院分区:
其他
文献类型:
--
作者:
Chaaban S;Zimmer A;Bhatt VR;Schmidt C;Sadikot RT

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异基因干细胞移植是一种挽救许多恶性肿瘤生命的治疗方法。移植后患者可能患有急性和/或慢性移植物抗宿主病(S)。移植后免疫缺陷是多种因素导致的发病率和死亡率的主要原因。此外,免疫抑制可能导致宿主因素的改变,使这些患者容易受到感染。尽管接受干细胞移植的患者患上包括真菌和病毒在内的机会性病原体的风险增加,但细菌感染仍然是发病的最常见原因。在这里,我们回顾了导致肺炎的细菌病原体,特别是在慢性GVHD人群中。
Allogeneic stem cell transplantation is a lifesaving treatment for many malignancies. Post-transplant patients may suffer from graft versus host disease in the acute and/or the chronic form(s). Post-transplantation immune deficiency due to a variety of factors is a major cause of morbidity and mortality. Furthermore, immunosuppression can lead to alterations in host factors that predisposes these patients to infections. Although patients who receive stem cell transplant are at an increased risk of opportunistic pathogens, which include fungi and viruses, bacterial infections remain the most common cause of morbidity. Here, we review bacterial pathogens that lead to pneumonias specifically in the chronic GVHD population.
DOI: 10.1111/j.1399-3062.2004.00068.x
发表时间: 2004-12-01
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