Host response assessment in recurring periodontitis
Host response assessment in recurring periodontitis
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DOI：
10.1111/j.1600-051x.1996.tb02085.x
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发表时间：
1996-03-01
影响因子：
6.7
通讯作者：
ODell, DS
中科院分区：
文献类型：
--
作者：
Ebersole, JL;Cappelli, D;ODell, DS
来自牙周炎患者的数据支持了牙周病微生物区系的选定成员的分布与血清和GCE中针对完整细菌的抗体水平之间的关系。这些数据与系统抗体一致，反映了宿主对与疾病活动相关的感染过程的反应。这份报告的目的是解决宿主抗体反应可能有助于阐明特定病原体的概念，并用于模拟复发性牙周炎未来牙周疾病进展的风险。这些来自成人牙周炎患者的研究结果表明，某些抗体特异性的升高与疾病复发的风险最密切相关。此外，对抗体升高频率的分析表明，能够在治疗后保持对这些病原体抗体升高的患者，可能表明个人风险较低。第二次调查是为了解决放线菌伴生性复发性牙周炎中宿主-寄生虫相互作用的问题。结果表明，在不同程度的复发患者中，局部和全身抗体反应和伴放线放线菌感染具有明显的特征。这些纵向研究证实了局部和/或全身抗体反应作为牙周病复发指标的可能性。
Data derived from periodontitis patients have provided support for a relationship between the distribution of selected members of the periodontopathic microbiota and antibody levels to the intact bacteria in both serum and GCE These data are consistent with the systemic antibody as a reflection of the host response to an infectious process associated with an episode of disease activity. The purpose of this report is to address the concept that the host antibody responses may help to elucidate the specific etiologic agents and be used to model the risk for future periodontal disease progression in recurring periodontitis. These findings from one study in adult periodontitis patients indicated that elevations in certain antibody specificities are most closely associated with patients exhibiting a risk of disease recurrence. Furthermore, analysis of the frequency of antibody elevations suggested that patients capable of maintaining elevated antibody to these pathogens post-treatment, may be indicative of an individual at less risk. A 2nd investigation was implemented to address questions concerning host-parasite interactions in A. actinomycetemcomitans-associated recurring periodontitis. The results showed distinctive characteristics of local and systemic antibody responses and A. actinomycetemcomitans infection in patients with varying extents of recurrent disease. These longitudinal studies developed evidence for the potential of local and/or systemic antibody responses as indicators of periodontal disease recurrence.