THE ARTERIOLES IN CASES OF HYPERTENSION
THE ARTERIOLES IN CASES OF HYPERTENSION
复制标题
高血压时的小动脉
DOI：
10.1001/archinte.1929.00140030094010
复制
发表时间：
1929
影响因子：
39
通讯作者：
N. M. Keith
中科院分区：
文献类型：
--
作者：
J. Kernohan;E. Anderson;N. M. Keith
在过去的六十年里，许多人研究了血管系统弥漫性疾病中小动脉的组织学变化。关于是否存在任何特征性病理损害存在相当大的争议。当眼科医生在恶性高血压病例中如此频繁地能够证明视网膜动脉和小动脉变窄时，我们对这个问题的兴趣又重新燃起。一年前，基思、瓦格纳和克诺汉（Kernohan）发现，在这种情况下，许多器官的小动脉和小动脉都有共同的特征，包括那些供应随意肌的小动脉和小动脉。后一项观察表明，来自流动高血压患者浅表肌肉的活检材料可能显示较小动脉的早期组织学变化。选择肌肉组织是因为它占身体的35%至40%，因此假设有广泛的病变
For the last sixty years many have studied the histologic changes in the smaller arteries in diffuse disease of the vascular system. There has been considerable controversy as to whether any characteristic pathologic lesion is present. Our interest in this subject was renewed when the ophthalmologist was so frequently able to demonstrate narrowing of the retinal arteries and arterioles in cases of malignant hypertension. A year ago Keith, Wagener and Kernohan 1 were able to show in such a case that there were common features in the smaller arteries and arterioles in many organs, including those supplying the voluntary muscle. The latter observation suggested that biopsy material from a superficial muscle in ambulatory cases of hypertension might show early histologic changes in the smaller arteries. Muscle tissue was chosen because it composes about 35 to 40 per cent of the body and thus an assumption that there is a widespread lesion