Quantitative assessment of cerebral ventricular volumes in chronic fatigue syndrome.
Quantitative assessment of cerebral ventricular volumes in chronic fatigue syndrome.
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DOI：
10.1207/s15324826an0801_4
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发表时间：
2001-01-01
影响因子：
--
通讯作者：
Natelson, B H
中科院分区：
文献类型：
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作者：
Lange, G;Holodny, A I;Natelson, B H
以前对慢性疲劳综合征（CFS）侧脑室增大的定性容量评估已经为一些CFS患者的大脑细微结构变化提供了证据。这项初步研究的目的是确定是否对侧室系统进行更敏感的定量评估将支持先前的定性研究结果。在这项研究中，我们比较了28名CFS参与者和15名对照者的总侧脑室容积以及左右半球亚成分。CFS组的心室容积大于对照组，差异接近统计学意义。未观察到组间心室不对称的差异。这项研究的结果进一步证明了慢性疲劳综合症参与者大脑中细微的病理生理变化。
Previous qualitative volumetric assessment of lateral ventricular enlargement in chronic fatigue syndrome (CFS) has provided evidence for subtle structural changes in the brains of some individuals with CFS. The aim of this pilot study was to determine whether a more sensitive quantitative assessment of the lateral ventricular system would support the previous qualitative findings. In this study, we compared the total lateral ventricular volume, as well as the right and left hemisphere subcomponents in 28 participants with CFS and 15 controls. Ventricular volumes in the CFS group were larger than in control groups, a difference that approached statistical significance. Group differences in ventricular asymmetry were not observed. The results of this study provide further evidence of subtle pathophysiological changes in the brains of participants with CFS.