Safety of ultrasonography in pregnancy: WHO systematic review of the literature and meta-analysis
Safety of ultrasonography in pregnancy: WHO systematic review of the literature and meta-analysis
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DOI：
10.1002/uog.6328
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发表时间：
2009-05-01
影响因子：
7.1
通讯作者：
Platt, L. D.
中科院分区：
文献类型：
--
作者：
Torloni, M. R.;Vedmedovska, N.;Platt, L. D.
目的在计划中的国际妇产科超声学会-世界卫生组织为制定国际应用的胎儿生长标准的多中心研究背景下，我们进行了一项系统回顾和荟萃分析，以评价妊娠期人体暴露于超声的安全性。方法系统检索电子数据库，对试验和观察性研究进行了参考列表和未发表的文献，这些试验和观察性研究评估了暴露于超声检查的短期和长期影响，涉及暴露于超声检查的妇女及其胎儿，在任何妊娠期使用B型或多普勒超声检查，不限次数结局指标为：（1）不良的母亲结局;（2）不良的围产期结局;（3）儿童期生长和神经发育异常;（4）非右利手;（5）儿童期恶性肿瘤;（6）智力表现和精神疾病。共有6.1篇出版物报告了来自41.包括不同的研究：16项对照试验，13项队列研究和12项病例对照研究。妊娠期超声检查与不良母体或围产期结局、身体或神经发育受损、儿童恶性肿瘤风险增加、智力低下或精神疾病无关。根据现有的临床试验，超声暴露与男孩非右利手之间的相关性较弱（OR 1.26，95%CI，1.03-1.54）。版权所有（C）世界卫生组织（2009）。
Objective In the context of the planned International Society of Ultrasound in Obstetrics and Gynecology-World Health Organization multicenter study for the development of fetal growth standards for international application, we conducted a systematic review and meta-analysis to evaluate the safety of human exposure to ultrasonography in pregnancy.Methods A systematic search of electronic databases, reference lists and unpublished literature was conducted for trials and observational studies that assessed short- and long-term effects of exposure to ultrasonography, involving women and their fetuses exposed to ultrasonograpby, using B-mode or Doppler sonography during any period of pregnancy, for any number of times. The outcome measures were: (1) adverse maternal outcome; (2) adverse perinatal outcome; (3) abnormal childhood growth and neurological development, (4) non-right handedness; (5) childhood malignancy; and (6) intellectual performance and mental disease.Results The electronic search identified 6716 citations, and 19 were identified from secondary sources. A total of 6.1 publications reporting data from 41. different studies were included: 16 controlled trials,13 cohort and 12 case-control studies. Ultrasonography in pregnancy was not associated with adverse maternal or perinatal outcome, impaired physical or neurological development, increased risk for malignancy in childhood, subnormal intellectual performance or mental diseases. According to the available clinical trials, there was a weak association between exposure to ultrasonograpby and non-right handedness in boys (odds ratio 1.26; 95% CI, 1.03-1.54).Conclusion According to the available evidence, exposure to diagnostic ultrasonography during pregnancy appears to be safe. Copyright (C) World Health Organization (2009).